Journal article
Molecular Epidemiology of Gram-Negative Bacteremia
Clinical infectious diseases, Vol.28(3), pp.605-610
03/1999
DOI: 10.1086/515151
PMID: 10194086
Abstract
We did pulsed field gel electrophoresis (PFGE) and antibiotic susceptibility testing on 202 gramnegative isolates obtained from blood cultures between 1 January 1989 and 31 December 1993. Seventy-eight patients had at least two gram-negative isolates of the same species recovered from blood drawn one or more days apart and met the other study criteria. Twenty patients had only 1 bloodstream infection, 48 patients had 1 recurrence of bacteremia, and 10 patients had >1 recurrence of bacteremia. Of 80 recurrences of bacteremia, 52 (65%) were relapses and 28 (35%) were reinfections. Seventy-eight percent of the episodes of bacteremia occurring ⩽300 days apart were relapses, and 100% occurring >300 days apart were reinfections (P < .001). Organisms causing recurrent bacteremia were not more resistant than those causing initial episodes. In conclusion, most episodes of recurrent gram-negative bacteremia were relapses. Relapses and reinfections could not be distinguished only by the length of time between episodes or by antimicrobial susceptibility patterns.
Details
- Title: Subtitle
- Molecular Epidemiology of Gram-Negative Bacteremia
- Creators
- Constanze Wendt - Department of Internal Medicine, Department of Pathology, The Program of Hospital Epidemiology, University of Iowa Hospitals and Clinics, and The Veterans Affairs Medical Center, Iowa City, IowaShawn A Messer - Department of Internal Medicine, Department of Pathology, The Program of Hospital Epidemiology, University of Iowa Hospitals and Clinics, and The Veterans Affairs Medical Center, Iowa City, IowaRichard J Hollis - Department of Internal Medicine, Department of Pathology, The Program of Hospital Epidemiology, University of Iowa Hospitals and Clinics, and The Veterans Affairs Medical Center, Iowa City, IowaMichael A Pfaller - Department of Internal Medicine, Department of Pathology, The Program of Hospital Epidemiology, University of Iowa Hospitals and Clinics, and The Veterans Affairs Medical Center, Iowa City, IowaRichard P Wenzel - Department of Internal Medicine, Department of Pathology, The Program of Hospital Epidemiology, University of Iowa Hospitals and Clinics, and The Veterans Affairs Medical Center, Iowa City, IowaLoreen A Herwaldt - Department of Internal Medicine, Department of Pathology, The Program of Hospital Epidemiology, University of Iowa Hospitals and Clinics, and The Veterans Affairs Medical Center, Iowa City, Iowa
- Resource Type
- Journal article
- Publication Details
- Clinical infectious diseases, Vol.28(3), pp.605-610
- Publisher
- The University of Chicago Press
- DOI
- 10.1086/515151
- PMID
- 10194086
- ISSN
- 1058-4838
- eISSN
- 1537-6591
- Language
- English
- Date published
- 03/1999
- Academic Unit
- Infectious Diseases; Epidemiology; Pathology; Internal Medicine
- Record Identifier
- 9984094778902771
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