Journal article
Molecular Genetic Strategies in the Study of Corticohippocampal Circuits
Cold Spring Harbor perspectives in biology, Vol.7(7), pp.a021725-20
07/01/2015
DOI: 10.1101/cshperspect.a021725
PMCID: PMC4484969
PMID: 26134320
Abstract
The first reproductively viable genetically modified mice were created in 1982 by Richard Palmiter and Ralph Brinster (Palmiter RD, Brinster RL, Hammer RE, Trumbauer ME, Rosenfeld MG, Birnberg NC, Evans RM. 1982. Dramatic growth of mice that develop from eggs microinjected with metallothionein-growth hormone fusion genes. Nature 300: 611-615). In the subsequent 30 plus years, numerous ground-breaking technical advancements in genetic manipulation have paved the way for improved spatially and temporally targeted research. Molecular genetic studies have been especially useful for probing the molecules and circuits underlying how organisms learn and remember—one of the most interesting and intensively investigated questions in neuroscience research. Here, we discuss selected genetic tools, focusing on corticohippocampal circuits and their implications for understanding learning and memory.
Details
- Title: Subtitle
- Molecular Genetic Strategies in the Study of Corticohippocampal Circuits
- Creators
- Christopher C Angelakos - Department of Biology, University of Pennsylvania, Philadelphia, Pennsylvania 19104-6018Ted Abel - Department of Biology, University of Pennsylvania, Philadelphia, Pennsylvania 19104-6018
- Resource Type
- Journal article
- Publication Details
- Cold Spring Harbor perspectives in biology, Vol.7(7), pp.a021725-20
- Publisher
- United States
- DOI
- 10.1101/cshperspect.a021725
- PMID
- 26134320
- PMCID
- PMC4484969
- ISSN
- 1943-0264
- eISSN
- 1943-0264
- Grant note
- U54 HD086984 / NICHD NIH HHS
- Language
- English
- Date published
- 07/01/2015
- Academic Unit
- Molecular Physiology and Biophysics; Psychiatry; Psychological and Brain Sciences; Iowa Neuroscience Institute; Neuroscience and Pharmacology; Biochemistry and Molecular Biology
- Record Identifier
- 9984070681902771
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