Journal article
Molecular Imaging of Cerebrovascular Lesions
Translational stroke research, Vol.5(2), pp.260-268
04/2014
DOI: 10.1007/s12975-013-0291-0
PMID: 24323714
Abstract
Inflammation is a key component in the pathogenesis of cerebrovascular lesions. Two agents have emerged as promising possibilities for imaging cerebrovascular lesions. These agents are ferumoxytol and myeloperoxidase (MPO)-specific paramagnetic magnetic resonance (MR) contrast agent. Ferumoxytol is an iron oxide nanoparticle coated by a carbohydrate shell that is used in MRI studies as an inflammatory marker as it is cleared by macrophages. Ferumoxytol-enhanced MRI allows noninvasive assessment of the inflammatory status of cerebral aneurysms and arteriovenous malformations and, possibly, may differentiate “unstable” lesions that require early intervention from “stable” lesions that can be safely observed. Several pilot studies have also suggested that MPO-specific paramagnetic MR contrast agent, di-5-hydroxytryptamide of gadopentetate dimeglumine, may allow imaging of inflammation in the wall of saccular aneurysms in animal models. However, studies in human subjects have yet to be performed. In this paper, we review current data regarding ferumoxytol-enhanced MRI and MPO-specific paramagnetic MR contrast agent and discuss current and future applications.
Details
- Title: Subtitle
- Molecular Imaging of Cerebrovascular Lesions
- Creators
- Nohra Chalouhi - Department of Neurosurgery Thomas Jefferson University and Jefferson Hospital for Neuroscience Philadelphia PA USAPascal Jabbour - Department of Neurosurgery Thomas Jefferson University and Jefferson Hospital for Neuroscience Philadelphia PA USAVincent Magnotta - Department of Neurosurgery University of Iowa Iowa City IA USADavid Hasan - University of Iowa Hospitals and Clinics 200 Hawkins Drive Iowa City IA 52242-1061 USA
- Resource Type
- Journal article
- Publication Details
- Translational stroke research, Vol.5(2), pp.260-268
- Publisher
- Springer US; Boston
- DOI
- 10.1007/s12975-013-0291-0
- PMID
- 24323714
- ISSN
- 1868-4483
- eISSN
- 1868-601X
- Language
- English
- Date published
- 04/2014
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Radiology; Psychiatry; Iowa Neuroscience Institute; Neurosurgery; Otolaryngology
- Record Identifier
- 9984040275402771
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