Journal article
Molecular Mechanisms of Sodium-Sensitive Hypertension in the Metabolic Syndrome
Current hypertension reports, Vol.19(8), pp.60-60
08/01/2017
DOI: 10.1007/s11906-017-0759-5
PMID: 28676941
Abstract
Purpose of Review We review the known mechanisms of sodium-sensitive hypertension in the metabolic syndrome with a focus on preclinical models, differences between these models, and methodological limitations. We also identify future directions for a better understanding and treatment of this common condition.
Recent Findings Rigorous methodologies to measure blood pressure in preclinical models may clarify some of the inconsistencies in the literature. Renal, neural, hormonal, and cardiovascular systems are dysregulated and contribute to elevated blood pressure. Local renin-angiotensin systems enhance systemic hormone signaling to increase blood pressure.
Summary Since the original description of metabolic syndrome, investigators from many fields have contributed to an increasingly complex and mechanistic understanding of this common condition. These systems integrate to regulate sodium transport in the kidney leading to hypertension and enhanced sodium sensitivity. An array of non-uniformpreclinical models are used and support clinical studies to inform which models are pathophysiologically relevant for further mechanistic studies to guide targeted therapy.
Details
- Title: Subtitle
- Molecular Mechanisms of Sodium-Sensitive Hypertension in the Metabolic Syndrome
- Creators
- Jonathan M. Nizar - Stanford UniversityVivek Bhalla - Stanford University
- Resource Type
- Journal article
- Publication Details
- Current hypertension reports, Vol.19(8), pp.60-60
- Publisher
- Springer Nature
- DOI
- 10.1007/s11906-017-0759-5
- PMID
- 28676941
- ISSN
- 1522-6417
- eISSN
- 1534-3111
- Number of pages
- 10
- Grant note
- 1R01 DK091565 / National Institutes of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA 16POST27770003 / American Heart Association Postdoctoral Fellowship on behalf of the Grossman Family
- Language
- English
- Date published
- 08/01/2017
- Academic Unit
- Nephrology; Internal Medicine
- Record Identifier
- 9984359871202771
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