Journal article
Molecular Predictors of Radiotherapy Response in Sarcoma
Current treatment options in oncology, Vol.17(1), pp.1-11
01/2016
DOI: 10.1007/s11864-015-0381-1
PMID: 26714494
Abstract
Soft-tissue sarcoma is one of the few clinical cancer models in which pre-operative radiotherapy is commonly utilized and in which tumor response to radiotherapy could be assessed. However, clinical and histopathological features of soft-tissue sarcomas are not useful in predicting tumor radiotherapy response. Exploration of predictive markers of sarcoma response to radiotherapy is further confounded by discordance between radiological tumor size reduction, pathological changes, and clinical local recurrence rates. The diversity of disease histology and anatomical origin further influences which type of radiotherapy response (volumetric vs. cytotoxic) would best relate to patient outcome. Advances in molecular biology and understanding of sarcoma biology have recently resulted in the identification of several molecular and imaging predictive markers of radiotherapy response. As the underlying mechanism of radiation-induced cell killing involves the production of DNA damage through the production of oxygen radicals, the most promising biomarkers and imaging markers are related to DNA damage repair genes, hypoxia, and tumor vasculature. As bone and cartilaginous sarcomas are less often treated with radiotherapy, biomarkers of response in these diseases are less examined.
Details
- Title: Subtitle
- Molecular Predictors of Radiotherapy Response in Sarcoma
- Creators
- Carlos Chan - Department of Surgery University of Iowa Carver College of Medicine 200 Hawkins Drive Iowa City IA 52242 USAPhilip Wong - Department of Radiation Oncology Centre Hospitalier de L’Université de Montréal 1560 Sherbrooke Street East Montreal QC Canada H2L 4M1
- Resource Type
- Journal article
- Publication Details
- Current treatment options in oncology, Vol.17(1), pp.1-11
- Publisher
- Springer US; New York
- DOI
- 10.1007/s11864-015-0381-1
- PMID
- 26714494
- ISSN
- 1527-2729
- eISSN
- 1534-6277
- Language
- English
- Date published
- 01/2016
- Academic Unit
- Surgery; Radiation Oncology
- Record Identifier
- 9984047609302771
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