Journal article
Molecular-Scale Tools for Studying Mechanotransduction
Annual review of biomedical engineering, Vol.17(1), pp.287-316
12/07/2015
DOI: 10.1146/annurev-bioeng-071114-040531
PMID: 26421895
Abstract
Mechanical stimuli are known to be potent regulators of the form and function of cells and organisms. Although biological regulation has classically been understood in terms of principles from solution biochemistry, advancements in many fields have led to the development of a suite of techniques that are able to reveal the interplay between mechanical loading and changes in the biochemical properties of proteins in systems ranging from single molecules to living organisms. Here, we review these techniques and highlight the emergence of a new molecular-scale understanding of the mechanisms mediating the detection and response of cells to mechanical stimuli, a process termed mechanotransduction. Specifically, we focus on the role of subcellular adhesion structures in sensing the stiffness of the surrounding environment because this process is pertinent to applications in tissue engineering as well the onset of several mechanosensitive disease states, including cancer.
Details
- Title: Subtitle
- Molecular-Scale Tools for Studying Mechanotransduction
- Creators
- Andrew S LaCroix - Duke UniversityKatheryn E Rothenberg - Duke UniversityBrenton D Hoffman - Duke University
- Resource Type
- Journal article
- Publication Details
- Annual review of biomedical engineering, Vol.17(1), pp.287-316
- DOI
- 10.1146/annurev-bioeng-071114-040531
- PMID
- 26421895
- eISBN
- 0824335171; 9780824335175
- ISSN
- 1523-9829
- eISSN
- 1545-4274
- Language
- English
- Date published
- 12/07/2015
- Academic Unit
- Biology
- Record Identifier
- 9984696714702771
Metrics
1 Record Views