Molecular, Serological, and Clinical Features of 16 Consecutive Cases of Invasive Streptococcal Disease

F R Cockerill III; R. L Thompson; J. M Musser; P. M Schlievert; J Talbot; K. E Holley; W. S Harmsen; D. M Ilstrup; P. C Kohner; M. H Kim; B Frankfort; J. M Manahan; J. M Steckelberg; F Roberson; W. R Wilson; Southeastern Minnesota Streptococcal Working Group

doi:10.1086/516376

Back

Molecular, Serological, and Clinical Features of 16 Consecutive Cases of Invasive Streptococcal Disease

Journal article

Open access

Peer reviewed

Molecular, Serological, and Clinical Features of 16 Consecutive Cases of Invasive Streptococcal Disease

F R Cockerill III, R. L Thompson, J. M Musser, P. M Schlievert, J Talbot, K. E Holley, W. S Harmsen, D. M Ilstrup, P. C Kohner, M. H Kim, …

Clinical infectious diseases, Vol.26(6), pp.1448-1458

06/1998

DOI: 10.1086/516376

PMID: 9636878

Files and links (1)

url

https://doi.org/10.1086/516376View

Published (Version of record) Open Access

Abstract

We performed a comprehensive analysis of the molecular, serological, and clinical features of 16 consecutive cases of invasive streptococcal disease (ISD). The majority of cases were linked to two group A streptococcus (GAS) clones closely related by pulsed-field gel electrophoresis (PFGE) and designated as PFGE-1 and PFGE-1.1. These clones, serotyped as M-3, T-3/B3264, carried an allelic variant of the gene that encodes pyrogenic exotoxin A (speA3) and the gene that encodes streptococcal superantigen (SSA) but different emm alleles that encode M-protein. The characteristics and clinical features of patients were similar to those described in previous reports, regardless of the responsible GAS clone. However, worse clinical outcomes (shock and death) were more frequent when patients infected with PFGE1/1.1 clones were considered as a group and compared with all other patients as a group. One striking feature in some patients with deep tissue infection was a lack of inflammatory cells despite the presence of numerous streptococci. An evaluation of PFGE profiles of GAS isolated elsewhere demonstrated that the PFGE-1 clone has caused invasive disease in other locations in the United States and in Japan.

Details

Title: Subtitle: Molecular, Serological, and Clinical Features of 16 Consecutive Cases of Invasive Streptococcal Disease
Creators: F R Cockerill III
R. L Thompson
J. M Musser
P. M Schlievert
J Talbot
K. E Holley
W. S Harmsen
D. M Ilstrup
P. C Kohner
M. H Kim
B Frankfort
J. M Manahan
J. M Steckelberg
F Roberson
W. R Wilson
Southeastern Minnesota Streptococcal Working Group
Resource Type: Journal article
Publication Details: Clinical infectious diseases, Vol.26(6), pp.1448-1458
DOI: 10.1086/516376
PMID: 9636878
ISSN: 1058-4838
eISSN: 1537-6591
Language: English
Date published: 06/1998
Academic Unit: Microbiology and Immunology; Internal Medicine
Record Identifier: 9984001126902771

Metrics

10 Record Views

48 Times Cited - Web of Science

See more details