Journal article
Molecular Tumor Board-Assisted Care in an Advanced Cancer Population: Results of a Phase II Clinical Trial
JCO precision oncology, Vol.6(6), e2100524
08/2022
DOI: 10.1200/PO.21.00524
PMCID: PMC9489195
PMID: 36103643
Abstract
Multidisciplinary molecular tumor boards (MTBs) interpret next-generation sequencing reports and help oncologists determine best therapeutic options; however, there is a paucity of data regarding their clinical utility. The purpose of this study was to determine if MTB-directed therapy improves progression-free survival (PFS) over immediately prior therapy in patients with advanced cancer.
This single-arm, prospective phase II clinical trial enrolled patients with advanced cancer with an actionable mutation who received MTB-recommended targeted therapy between January 1, 2017, and October 31, 2020. MTB-recommended both on-label (level 1 evidence) and off-label (evidence levels 2 and 3) therapies. Of the 93 enrolled patients, 43 were treated frontline and 50 received second-line or greater-line therapy. The primary outcome was the probability of patients treated with second-line or greater-line MTB-directed therapy who achieved a PFS ratio ≥ 1.3 (PFS on MTB-directed therapy divided by PFS on the patient's immediately prior therapy). Secondary outcomes included PFS for patients treated frontline and overall survival and adverse effects for the entire study population.
The most common disease sites were lung (35 of 93, 38%), gynecologic (17 of 93, 18%), GI (16 of 93, 17%), and head and neck (7 of 93, 8%). The Kaplan-Meier estimate of the probability of PFS ratio ≥ 1.3 was 0.59 (95% CI, 0.47 to 0.75) for patients treated with second-line or greater-line MTB-directed therapy. The median PFS was 449 (range 42-1,125) days for patients treated frontline. The median overall survival was 768 (range 22-1,240) days. There were four nontreatment-related deaths.
When treated with MTB-directed therapy, most patients experienced improved PFS compared with immediately prior treatment. MTB-directed targeted therapy may be a strategy to improve outcomes for patients with advanced cancer.
Details
- Title: Subtitle
- Molecular Tumor Board-Assisted Care in an Advanced Cancer Population: Results of a Phase II Clinical Trial
- Creators
- Rachel W Miller - Markey Cancer CenterMegan L Hutchcraft - Markey Cancer CenterHeidi L Weiss - University of KentuckyJianrong Wu - University of KentuckyChi Wang - University of KentuckyJinpeng Liu - Markey Cancer CenterRani Jayswal - University of KentuckyMikayla Buchanan - Markey Cancer CenterAbigail Anderson - Markey Cancer CenterDerek B Allison - University of KentuckyRiham H El Khouli - University of KentuckyReema A Patel - University of KentuckyJohn L Villano - University of KentuckySusanne M Arnold - Markey Cancer CenterJill M Kolesar - University of Kentucky
- Resource Type
- Journal article
- Publication Details
- JCO precision oncology, Vol.6(6), e2100524
- DOI
- 10.1200/PO.21.00524
- PMID
- 36103643
- PMCID
- PMC9489195
- ISSN
- 2473-4284
- eISSN
- 2473-4284
- Language
- English
- Date published
- 08/2022
- Academic Unit
- Pharmacy; Pharmaceutical Sciences and Experimental Therapeutics
- Record Identifier
- 9984695795802771
Metrics
9 Record Views