Journal article
Molecular analysis of pyrogenic exotoxins from Streptococcus pyogenes isolates associated with toxic shock-like syndrome
Journal of clinical microbiology, Vol.29(8), pp.1562-1567
08/1991
DOI: 10.1128/jcm.29.8.1562-1567.1991
PMCID: PMC270163
PMID: 1684795
Abstract
Toxic shock-like syndrome (TSLS) is characterized by hypotension or shock, fever, multiorgan system involvement, and a concurrent group A streptococcal infection. We analyzed 34 streptococcal strains isolated from patients with clinically well-documented TSLS for their pyrogenic toxin profiles and M-protein types. Although strains of nine different M types were represented in the sample, 74% of the isolates were of either M type 1 or 3. It was determined that 53% produced streptococcal pyrogenic exotoxin type A under in vitro growth conditions and that 85% contained the gene encoding this toxin. These values are in contrast to the published value of 15% for the incidence of this gene in a sample of general group A streptococcal isolates. As has been found with all group A streptococci examined to date, regardless of disease association, 100% of TSLS-associated isolates contained the gene encoding pyrogenic exotoxin type B. This toxin was detectably produced by 59% of isolates. The gene encoding pyrogenic toxin type C was found in only 21% of isolates. We conclude that the pyrogenic exotoxin type A gene is associated with group A streptococcal strains isolated from patients with TSLS and may play a causative role in this illness. However, other factors are also likely to be important, since not all strains from patients with TSLS contained the A toxin gene.
Details
- Title: Subtitle
- Molecular analysis of pyrogenic exotoxins from Streptococcus pyogenes isolates associated with toxic shock-like syndrome
- Creators
- Alan R Hauser - Department of Microbiology, University of Minnesota, Minneapolis 55455Dennis L Stevens - Department of Microbiology, University of Minnesota, Minneapolis 55455Edward L Kaplan - Department of Microbiology, University of Minnesota, Minneapolis 55455Patrick M Schlievert - Department of Microbiology, University of Minnesota, Minneapolis 55455
- Resource Type
- Journal article
- Publication Details
- Journal of clinical microbiology, Vol.29(8), pp.1562-1567
- DOI
- 10.1128/jcm.29.8.1562-1567.1991
- PMID
- 1684795
- PMCID
- PMC270163
- ISSN
- 0095-1137
- eISSN
- 1098-660X
- Language
- English
- Date published
- 08/1991
- Academic Unit
- Microbiology and Immunology; Internal Medicine
- Record Identifier
- 9984001122202771
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