Journal article
Molecular characterization and survival analysis of a cohort of glioblastoma, IDH-wildtype
Pathology, research and practice, Vol.257, 155272
05/2024
DOI: 10.1016/j.prp.2024.155272
PMID: 38631135
Abstract
Glioblastoma, IDH-wild type, the most common malignant primary central nervous system tumor, represents a formidable challenge in clinical management due to its poor prognosis and limited therapeutic responses. With an evolving understanding of its underlying biology, there is an urgent need to identify prognostic molecular groups that can be subject to targeted therapy. This study established a cohort of 124 sequential glioblastomas from a tertiary hospital and aimed to find correlations between molecular features and survival outcomes. Comprehensive molecular characterization of the cohort revealed prevalent alterations as previously described, such as TERT promoter mutations and involvement of the PI3K-Akt-mTOR, CK4/6-CDKN2A/B-RB1, and p14ARF-MDM2-MDM4-p53 pathways. MGMT promoter methylation is a significant predictor of improved overall survival, aligned with previous data. Conversely, age showed a marginal association with higher mortality. Multivariate analysis to account for the effect of MGMT promoter methylation and age showed that, in contrast to other published series, this cohort demonstrated improved survival for tumors harboring PTEN mutations, and that there was no observed difference for most other molecular alterations, including EGFR amplification, RB1 loss, or the coexistence of EGFR amplification and deletion/exon skipping (EGFRvIII). Despite limitations in sample size, this study contributes data to the molecular landscape of glioblastomas, prompting further investigations to examine these findings more closely in larger cohorts.
Details
- Title: Subtitle
- Molecular characterization and survival analysis of a cohort of glioblastoma, IDH-wildtype
- Creators
- Bilge Dundar - Mayo Clinic in ArizonaMouaz Alsawas - University of IowaAmr Masaadeh - University of IowaKyle Conway - University of Michigan–Ann ArborAnthony N. Snow - University of IowaRamakrishna R. Sompallae - University of IowaAaron D. Bossler - Moffitt Cancer CenterDeqin Ma - University of IowaOsorio Lopes Abath Neto - Department of Pathology, University of Iowa Hospitals and Clinics, Iowa City, IA, USA
- Resource Type
- Journal article
- Publication Details
- Pathology, research and practice, Vol.257, 155272
- Publisher
- Elsevier GmbH
- DOI
- 10.1016/j.prp.2024.155272
- PMID
- 38631135
- ISSN
- 0344-0338
- eISSN
- 1618-0631
- Language
- English
- Date published
- 05/2024
- Academic Unit
- Pathology
- Record Identifier
- 9984617009202771
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