Journal article
Molecular characterization of ovarian tumors in drosophila
Mechanisms of development, Vol.47(2), pp.151-164
1994
DOI: 10.1016/0925-4773(94)90087-6
PMID: 7811638
Abstract
Certain female-sterile mutations in
Drosophila result in the uncontrolled proliferation of
X/X germ cells. It has been proposed that this ovarian tumor phenotype results from the sexual transformation of
X/X germ cells to a male identity. We present findings inconsistent with this model. We demonstrate that the tumorous cells produced by mutations in the
ovarian tumor (
otu),
Sex-lethal (
Sxl) and
sans fille (
snf) genes are capable of female-specific transcription and RNA processing. This indicates that these ovarian tumor cells still retain some female identity. Therefore, we propose that mutations in these genes do not cause a male transformation of the
X/X germ line but instead either cause an ambiguous sexual identity or block specific stages of oogenesis. Our findings indicate that while
Sxl is the master sex determination gene in somatic cells, it appears to play a more subsidiary role in the germ line. Finally, we demonstrate that the germ line function of
Sxl depends on the activity of a specific OTU isoform.
Details
- Title: Subtitle
- Molecular characterization of ovarian tumors in drosophila
- Creators
- Eunkyung Bae - Department of Biological Sciences, University of Iowa, Iowa City, Iowa 52242-1234, USAKevin R Cook - Department of Biological Sciences, University of Iowa, Iowa City, Iowa 52242-1234, USAPamela K Geyer - Department of Biochemistry, University of Iowa, Iowa City, Iowa 52242-1234, USARod N Nagoshi - Department of Biological Sciences, University of Iowa, Iowa City, Iowa 52242-1234, USA
- Resource Type
- Journal article
- Publication Details
- Mechanisms of development, Vol.47(2), pp.151-164
- DOI
- 10.1016/0925-4773(94)90087-6
- PMID
- 7811638
- NLM abbreviation
- Mech Dev
- ISSN
- 0925-4773
- eISSN
- 1872-6356
- Publisher
- Elsevier Ireland Ltd
- Language
- English
- Date published
- 1994
- Academic Unit
- Obstetrics and Gynecology; Biochemistry and Molecular Biology
- Record Identifier
- 9984025271802771
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