Molecular epidemiology of hepatitis B, C, D and E viruses among children in Moscow, Russia

Kenji Abe; Eriko Hayakawa; Andrei V Sminov; Anna L Rossina; Xin Ding; Tran T-T Huy; Tetsutaro Sata; Vasily F Uchaikin

doi:10.1016/j.jcv.2003.08.009

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Molecular epidemiology of hepatitis B, C, D and E viruses among children in Moscow, Russia

Journal article

Peer reviewed

Molecular epidemiology of hepatitis B, C, D and E viruses among children in Moscow, Russia

Kenji Abe, Eriko Hayakawa, Andrei V Sminov, Anna L Rossina, Xin Ding, Tran T-T Huy, Tetsutaro Sata and Vasily F Uchaikin

Journal of clinical virology, Vol.30(1), pp.57-61

2004

DOI: 10.1016/j.jcv.2003.08.009

PMID: 15072755

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Abstract

Background: It is known that the prevalence of HBV and HCV infections vary according to geographical areas. However, in Russia, an adequate level of information on the molecular epidemiology of hepatitis viruses has not been available so far. Objectives: To investigate the characterization of various hepatitis viruses in Russia, we conducted molecular-based epidemiological survey of hepatitis viruses including hepatitis B virus (HBV), hepatitis C virus (HCV), hepatitis D virus (HDV) and hepatitis E virus (HEV) among children in Moscow, Russia. Study design: The study population of 374 subjects (ranging in age from 1 to 14 years old) consisted of 195 patients with liver diseases and 179 patients without liver diseases. Viral DNA/RNA was determined by nested PCR. Genotyping of HBV and HCV were examined by PCR using type-specific primers. Anti-HEV antibody was assayed by ELISA. Results: The infection rate of each virus among patients with liver diseases including acute hepatitis, chronic hepatitis or cirrhosis was 65.6% for HBV and 15.9% for HCV. In contrast, among non-liver disease patients, the infection rates were 14.4% for HBV and 0.6% for HCV, respectively. The most common viral genotypes were type D (85%) of HBV and type 1b (79.3%) of HCV. HDV RNA was detected in 7 of 149 (4.7%) HBV DNA-positive children tested. Moreover, testing for HEV among 341 subjects resulted in the detection of anti-HEV IgG in 62 cases (18.2%). Conclusions: Our results suggest that HBV infection is widespread in Moscow and have led to a high incidence of acute and chronic liver diseases among children in this region.

Hepatitis D virus (HDV)

Genotypic distribution of HBV and HCV

Moscow, Russia

Hepatitis C virus (HCV)

Hepatitis B virus (HBV)

Hepatitis E virus (HEV)

Details

Title: Subtitle: Molecular epidemiology of hepatitis B, C, D and E viruses among children in Moscow, Russia
Creators: Kenji Abe - Department of Pathology, National Institute of Infectious Diseases, Toyama 1-23-1, Shinjuku-ku, Tokyo 162-8640, Japan
Eriko Hayakawa - Department of Pathology, National Institute of Infectious Diseases, Toyama 1-23-1, Shinjuku-ku, Tokyo 162-8640, Japan
Andrei V Sminov - Department of Children Infectious Diseases, Russian State Medical University, Moscow, Russia
Anna L Rossina - Department of Children Infectious Diseases, Russian State Medical University, Moscow, Russia
Xin Ding - Department of Pathology, National Institute of Infectious Diseases, Toyama 1-23-1, Shinjuku-ku, Tokyo 162-8640, Japan
Tran T-T Huy - Department of Pathology, National Institute of Infectious Diseases, Toyama 1-23-1, Shinjuku-ku, Tokyo 162-8640, Japan
Tetsutaro Sata - Department of Pathology, National Institute of Infectious Diseases, Toyama 1-23-1, Shinjuku-ku, Tokyo 162-8640, Japan
Vasily F Uchaikin - Department of Children Infectious Diseases, Russian State Medical University, Moscow, Russia
Resource Type: Journal article
Publication Details: Journal of clinical virology, Vol.30(1), pp.57-61
DOI: 10.1016/j.jcv.2003.08.009
PMID: 15072755
NLM abbreviation: J Clin Virol
ISSN: 1386-6532
eISSN: 1873-5967
Publisher: Elsevier B.V
Language: English
Date published: 2004
Academic Unit: Gastroenterology and Hepatology; Internal Medicine
Record Identifier: 9984094638502771

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