Molecular epidemiology of macrolide resistance in neonatal bloodstream isolates of group B streptococci

Daniel J Diekema; Janet I Andrews; Holly Huynh; Paul R Rhomberg; Stella R Doktor; Jill Beyer; Virginia D Shortridge; Robert K Flamm; Ronald N Jones; Michael A Pfaller

doi:10.1128/JCM.41.6.2659-2661.2003

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Molecular epidemiology of macrolide resistance in neonatal bloodstream isolates of group B streptococci

Journal article

Open access

Peer reviewed

Molecular epidemiology of macrolide resistance in neonatal bloodstream isolates of group B streptococci

Daniel J Diekema, Janet I Andrews, Holly Huynh, Paul R Rhomberg, Stella R Doktor, Jill Beyer, Virginia D Shortridge, Robert K Flamm, Ronald N Jones and Michael A Pfaller

Journal of clinical microbiology, Vol.41(6), pp.2659-2661

06/2003

DOI: 10.1128/JCM.41.6.2659-2661.2003

PMCID: PMC156484

PMID: 12791897

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Abstract

Pulsed-field gel electrophoresis (PFGE) was performed on 122 neonatal bloodstream isolates of group B streptococci (GBS) to further examine the relationship between macrolide resistance and serotype V GBS (GBS-V). Over one-third (35%) of macrolide-resistant GBS belonged to a single PFGE subtype of GBS-V, which was also the most common GBS-V subtype noted in previous Centers for Disease Control and Prevention surveillance studies. Erm methylase (ermA and ermB) was the most common resistance mechanism detected, present in 12 of 20 macrolide-resistant GBS.

Streptococcal Infections - microbiology

Streptococcus agalactiae - drug effects

Macrolides

Humans

Bacterial Proteins - genetics

Methyltransferases - genetics

Streptococcus agalactiae - classification

Blood - microbiology

Electrophoresis, Gel, Pulsed-Field

Bacteremia - microbiology

Microbial Sensitivity Tests

Streptococcus agalactiae - genetics

Streptococcus agalactiae - isolation & purification

Molecular Epidemiology

Anti-Bacterial Agents - pharmacology

Drug Resistance, Bacterial - genetics

Infant, Newborn

Serotyping

Details

Title: Subtitle: Molecular epidemiology of macrolide resistance in neonatal bloodstream isolates of group B streptococci
Creators: Daniel J Diekema - Department of Internal Medicine, University of Iowa Colleges of Medicine and Public Health, Iowa City, Iowa 52242, USA. daniel-diekema@uiowa.edu
Janet I Andrews
Holly Huynh
Paul R Rhomberg
Stella R Doktor
Jill Beyer
Virginia D Shortridge
Robert K Flamm
Ronald N Jones
Michael A Pfaller
Resource Type: Journal article
Publication Details: Journal of clinical microbiology, Vol.41(6), pp.2659-2661
DOI: 10.1128/JCM.41.6.2659-2661.2003
PMID: 12791897
PMCID: PMC156484
NLM abbreviation: J Clin Microbiol
ISSN: 0095-1137
eISSN: 1098-660X
Publisher: United States
Language: English
Date published: 06/2003
Academic Unit: Infectious Diseases; Epidemiology; Pathology; Obstetrics and Gynecology; Internal Medicine
Record Identifier: 9983986366702771

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