Molecular evolution of the insect-specific flaviviruses

Shelley Cook; Gregory Moureau; Andrew Kitchen; Ernest A Gould; Xavier de Lamballerie; Edward C Holmes; Ralph E Harbach

doi:10.1099/vir.0.036525-0

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Molecular evolution of the insect-specific flaviviruses

Journal article

Open access

Peer reviewed

Molecular evolution of the insect-specific flaviviruses

Shelley Cook, Gregory Moureau, Andrew Kitchen, Ernest A Gould, Xavier de Lamballerie, Edward C Holmes and Ralph E Harbach

Journal of general virology, Vol.93(Pt 2), pp.223-234

02/2012

DOI: 10.1099/vir.0.036525-0

PMCID: PMC3352342

PMID: 22012464

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Abstract

There has been an explosion in the discovery of 'insect-specific' flaviviruses and/or their related sequences in natural mosquito populations. Herein we review all 'insect-specific' flavivirus sequences currently available and conduct phylogenetic analyses of both the 'insect-specific' flaviviruses and available sequences of the entire genus Flavivirus. We show that there is no statistical support for virus-mosquito co-divergence, suggesting that the 'insect-specific' flaviviruses may have undergone multiple introductions with frequent host switching. We discuss potential implications for the evolution of vectoring within the family Flaviviridae. We also provide preliminary evidence for potential recombination events in the history of cell fusing agent virus. Finally, we consider priorities and guidelines for future research on 'insect-specific' flaviviruses, including the vast potential that exists for the study of biodiversity within a range of potential hosts and vectors, and its effect on the emergence and maintenance of the flaviviruses.

Insecta - virology

Animals

RNA, Viral - genetics

Flavivirus - isolation & purification

Flavivirus - genetics

Phylogeny

Flavivirus - classification

Cluster Analysis

Evolution, Molecular

Details

Title: Subtitle: Molecular evolution of the insect-specific flaviviruses
Creators: Shelley Cook - Natural History Museum, Cromwell Road, London SW7 5BD, UK
Gregory Moureau - Unité des Virus Emergents UMR190, Université de la Méditerranée, Institut de Recherche pour le Développement, EHESP French School of Public Health, Marseille, France
Andrew Kitchen - Center for Infectious Disease Dynamics, Department of Biology, The Pennsylvania State University, University Park, PA 16802, USA
Ernest A Gould - Unité des Virus Emergents UMR190, Université de la Méditerranée, Institut de Recherche pour le Développement, EHESP French School of Public Health, Marseille, France
Xavier de Lamballerie - Unité des Virus Emergents UMR190, Université de la Méditerranée, Institut de Recherche pour le Développement, EHESP French School of Public Health, Marseille, France
Edward C Holmes - Center for Infectious Disease Dynamics, Department of Biology, The Pennsylvania State University, University Park, PA 16802, USA
Ralph E Harbach - Natural History Museum, Cromwell Road, London SW7 5BD, UK
Resource Type: Journal article
Publication Details: Journal of general virology, Vol.93(Pt 2), pp.223-234
DOI: 10.1099/vir.0.036525-0
PMID: 22012464
PMCID: PMC3352342
NLM abbreviation: J Gen Virol
ISSN: 1465-2099
eISSN: 1465-2099
Publisher: England
Grant note: 039833 / Wellcome Trust
Language: English
Date published: 02/2012
Academic Unit: Anthropology; International Programs
Record Identifier: 9983983665502771

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