Journal article
Molecular evolutionary dynamics of Ross River virus and implications for vaccine efficacy
Journal of general virology, Vol.91(Pt 1), pp.182-188
01/2010
DOI: 10.1099/vir.0.014209-0
PMID: 19759236
Abstract
Ross River virus (RRV) is a mosquito-borne member of the genus Alphavirus that causes epidemic polyarthritis in humans, costing the Australian health system at least US$10 million annually. Recent progress in RRV vaccine development requires accurate assessment of RRV genetic diversity and evolution, particularly as they may affect the utility of future vaccination. In this study, we provide novel RRV genome sequences and investigate the evolutionary dynamics of RRV from time-structured E2 gene datasets. Our analysis indicates that, although RRV evolves at a similar rate to other alphaviruses (mean evolutionary rate of approx. 8x10(-4) nucleotide substitutions per site year(-1)), the relative genetic diversity of RRV has been continuously low through time, possibly as a result of purifying selection imposed by replication in a wide range of natural host and vector species. Together, these findings suggest that vaccination against RRV is unlikely to result in the rapid antigenic evolution that could compromise the future efficacy of current RRV vaccines.
Details
- Title: Subtitle
- Molecular evolutionary dynamics of Ross River virus and implications for vaccine efficacy
- Creators
- Anita Jones - Institute of Health and Biomedical Innovation, Queensland University of Technology, 60 Musk Avenue, Brisbane 4059, AustraliaKym LowryJohn AaskovEdward C HolmesAndrew Kitchen
- Resource Type
- Journal article
- Publication Details
- Journal of general virology, Vol.91(Pt 1), pp.182-188
- DOI
- 10.1099/vir.0.014209-0
- PMID
- 19759236
- NLM abbreviation
- J Gen Virol
- ISSN
- 1465-2099
- eISSN
- 1465-2099
- Publisher
- England
- Language
- English
- Date published
- 01/2010
- Academic Unit
- Anthropology; International Programs
- Record Identifier
- 9983984532802771
Metrics
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