Journal article
Molecular markers of cardiomyopathy in cyanotic pediatric heart disease
Progress in pediatric cardiology, Vol.32(1), pp.19-23
2011
DOI: 10.1016/j.ppedcard.2011.06.005
Abstract
Cyanotic congenital heart disease (CHD) accounts for approximately 25% of all types of CHD, encompassing a variety of cardiac anomalies. Children with cyanotic CHD are at risk for heart failure, cardiomyopathy, and arrhythmias. In addition to the hemodynamic burden, recent data suggest that hypoxia may contribute to heart failure. Previous studies have shown that neonatal hypoxia results in significant myocardial gene expression alterations that persist in adulthood after the termination of the hypoxic stimulus in the neonatal period or early infancy. In this article we review the current knowledge on molecular biomarkers of cyanotic CHD pathobiology, and expand on how the current knowledge establishes the basis for future studies to further define the role of molecular tools in cyanotic CHD to improve diagnostic, prognostic and therapeutic strategies.
Details
- Title: Subtitle
- Molecular markers of cardiomyopathy in cyanotic pediatric heart disease
- Creators
- Marco Ricci - University of MiamiJoy Lincoln - University of Miami
- Resource Type
- Journal article
- Publication Details
- Progress in pediatric cardiology, Vol.32(1), pp.19-23
- DOI
- 10.1016/j.ppedcard.2011.06.005
- ISSN
- 1058-9813
- eISSN
- 1558-1519
- Publisher
- Elsevier Ireland Ltd
- Grant note
- Jonathan and Eileen Otto Research Fund 1R01HL091878 / NIH NHLBI
- Language
- English
- Date published
- 2011
- Academic Unit
- Cardiothoracic Surgery
- Record Identifier
- 9984322874002771
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