Journal article
Molecular mechanisms for myocardial mitochondrial dysfunction in the metabolic syndrome
Clinical science (1979), Vol.114(3), pp.195-210
02/2008
DOI: 10.1042/CS20070166
PMID: 18184113
Abstract
The metabolic syndrome represents a cluster of abnormalities, including obesity, insulin resistance, dyslipidaemia and Type 2 diabetes, that increases the risk of developing cardiovascular diseases, such as coronary artery disease and heart failure. The heart failure risk is increased even after adjusting for coronary artery disease and hypertension, and evidence is emerging that changes in cardiac energy metabolism might contribute to the development of contractile dysfunction. Recent findings suggest that myocardial mitochondrial dysfunction may play an important role in the pathogenesis of cardiac contractile dysfunction in obesity, insulin resistance and Type 2 diabetes. This review will discuss potential molecular mechanisms for these mitochondrial abnormalities.
Details
- Title: Subtitle
- Molecular mechanisms for myocardial mitochondrial dysfunction in the metabolic syndrome
- Creators
- Heiko Bugger - Division of Endocrinology, Metabolism and Diabetes, Program in Human Molecular Biology and Genetics, University of Utah School of Medicine, Salt Lake City, UT 84112, USAE Dale Abel
- Resource Type
- Journal article
- Publication Details
- Clinical science (1979), Vol.114(3), pp.195-210
- Publisher
- England
- DOI
- 10.1042/CS20070166
- PMID
- 18184113
- ISSN
- 0143-5221
- eISSN
- 1470-8736
- Grant note
- UO1HL70525 / NHLBI NIH HHS R01 HL73167 / NHLBI NIH HHS UO1 HL087947 / NHLBI NIH HHS R01 HL70070 / NHLBI NIH HHS
- Language
- English
- Date published
- 02/2008
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Fraternal Order of Eagles Diabetes Research Center; Biochemistry and Molecular Biology; Endocrinology and Metabolism; Internal Medicine
- Record Identifier
- 9984024410002771
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