Molecular mechanisms of diabetic cardiomyopathy

Heiko Bugger; E Dale Abel

doi:10.1007/s00125-014-3171-6

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Molecular mechanisms of diabetic cardiomyopathy

Journal article

Open access

Peer reviewed

Molecular mechanisms of diabetic cardiomyopathy

Heiko Bugger and E Dale Abel

Diabetologia, Vol.57(4), pp.660-671

04/2014

DOI: 10.1007/s00125-014-3171-6

PMCID: PMC3969857

PMID: 24477973

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Abstract

In recent years, diabetes mellitus has become an epidemic and now represents one of the most prevalent disorders. Cardiovascular complications are the major cause of mortality and morbidity in diabetic patients. While ischaemic events dominate the cardiac complications of diabetes, it is widely recognised that the risk for developing heart failure is also increased in the absence of overt myocardial ischaemia and hypertension or is accelerated in the presence of these comorbidities. These diabetes-associated changes in myocardial structure and function have been called diabetic cardiomyopathy. Numerous molecular mechanisms have been proposed to contribute to the development of diabetic cardiomyopathy following analysis of various animal models of type 1 or type 2 diabetes and in genetically modified mouse models. The steady increase in reports presenting novel mechanistic data on this subject expands the list of potential underlying mechanisms. The current review provides an update on molecular alterations that may contribute to the structural and functional alterations in the diabetic heart.

Diabetic Cardiomyopathies - metabolism

Diabetic Cardiomyopathies - etiology

Humans

Diabetes Mellitus, Type 1 - pathology

Diabetes Mellitus, Type 1 - metabolism

Heart Failure - metabolism

Diabetes Mellitus, Type 1 - complications

Diabetes Mellitus, Type 2 - metabolism

Heart Failure - pathology

Animals

Diabetic Cardiomyopathies - pathology

Diabetes Mellitus, Type 2 - pathology

Heart Failure - etiology

Diabetes Mellitus, Type 2 - complications

Details

Title: Subtitle: Molecular mechanisms of diabetic cardiomyopathy
Creators: Heiko Bugger - Cardiology and Angiology I, Heart Center Freiburg University, Freiburg, Germany
E Dale Abel
Resource Type: Journal article
Publication Details: Diabetologia, Vol.57(4), pp.660-671
Publisher: Germany
DOI: 10.1007/s00125-014-3171-6
PMID: 24477973
PMCID: PMC3969857
ISSN: 0012-186X
eISSN: 1432-0428
Grant note: R01 HL108379 / NHLBI NIH HHS R01 DK092065 / NIDDK NIH HHS U01 HL087947 / NHLBI NIH HHS
Language: English
Date published: 04/2014
Academic Unit: Roy J. Carver Department of Biomedical Engineering; Fraternal Order of Eagles Diabetes Research Center; Biochemistry and Molecular Biology; Endocrinology and Metabolism; Internal Medicine
Record Identifier: 9984025263202771

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