Journal article
Molecular mechanisms underlying neuronal synaptic plasticity: systems biology meets computational neuroscience in the wilds of synaptic plasticity
Wiley interdisciplinary reviews. Systems biology and medicine, Vol.5(6), pp.717-731
11/2013
DOI: 10.1002/wsbm.1240
PMCID: PMC3947422
PMID: 24019266
Abstract
Interactions among signaling pathways that are activated by transmembrane receptors produce complex networks and emergent dynamical behaviors that are implicated in synaptic plasticity. Temporal dynamics and spatial aspects are critical determinants of cell responses such as synaptic plasticity, although the mapping between spatiotemporal activity pattern and direction of synaptic plasticity is not completely understood. Computational modeling of neuronal signaling pathways has significantly contributed to understanding signaling pathways underlying synaptic plasticity. Spatial models of signaling pathways in hippocampal neurons have revealed mechanisms underlying the spatial distribution of extracellular signal-related kinase (ERK) activation in hippocampal neurons. Other spatial models have demonstrated that the major role of anchoring proteins in striatal and hippocampal synaptic plasticity is to place molecules near their activators. Simulations of yet other models have revealed that the spatial distribution of synaptic plasticity may differ for potentiation versus depression. In general, the most significant advances have been made by interactive modeling and experiments; thus, an interdisciplinary approach should be applied to investigate critical issues in neuronal signaling pathways. These issues include identifying which transmembrane receptors are key for activating ERK in neurons, and the crucial targets of kinases that produce long-lasting synaptic plasticity. Although the number of computer programs for computationally efficient simulation of large reaction-diffusion networks is increasing, parameter estimation and sensitivity analysis in these spatial models remain more difficult than in single compartment models. Advances in live cell imaging coupled with further software development will continue to accelerate the development of spatial models of synaptic plasticity. (C) 2013 Wiley Periodicals, Inc.
Details
- Title: Subtitle
- Molecular mechanisms underlying neuronal synaptic plasticity: systems biology meets computational neuroscience in the wilds of synaptic plasticity
- Creators
- Kim T. Blackwell - George Mason UniversityJoanna Jedrzejewska-Szmek - George Mason University
- Resource Type
- Journal article
- Publication Details
- Wiley interdisciplinary reviews. Systems biology and medicine, Vol.5(6), pp.717-731
- DOI
- 10.1002/wsbm.1240
- PMID
- 24019266
- PMCID
- PMC3947422
- NLM abbreviation
- Wiley Interdiscip Rev Syst Biol Med
- ISSN
- 1939-5094
- eISSN
- 1939-005X
- Publisher
- Wiley
- Number of pages
- 15
- Grant note
- MURI N00014-10-1-0198 / ONR; Office of Naval Research NIH R01 AA18060 / NIH-NSF CRCNS program R01AA018060 / NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute on Alcohol Abuse & Alcoholism (NIAAA)
- Language
- English
- Date published
- 11/2013
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Iowa Neuroscience Institute
- Record Identifier
- 9984446266802771
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