Molecular mimicry between S peplomer proteins of coronaviruses (MHV, BCV, TGEV and IBV) and Fc receptor

E L Oleszak; S Perlman; R Parr; E W Collisson; J L Leibowitz

doi:10.1007/978-1-4615-2996-5_29

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Molecular mimicry between S peplomer proteins of coronaviruses (MHV, BCV, TGEV and IBV) and Fc receptor

Journal article

Open access

Peer reviewed

Molecular mimicry between S peplomer proteins of coronaviruses (MHV, BCV, TGEV and IBV) and Fc receptor

E L Oleszak, S Perlman, R Parr, E W Collisson and J L Leibowitz

Advances in experimental medicine and biology, Vol.342, pp.183-188

1993

DOI: 10.1007/978-1-4615-2996-5_29

PMID: 8209728

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Abstract

In previous studies we have demonstrated molecular mimicry between the S peplomer protein of Mouse Hepatitis Virus (MHV) and Fc gamma Receptor (Fc gamma R) of IgG. Rabbit IgG, but not its F(ab')2 fragments, monoclonal rat and mouse IgG and the rat 2.4G2 anti-mouse Fc gamma R monoclonal antibody (mab) immunoprecipitated natural and recombinant MHV S protein. On the basis of a number of criteria, MHV S peplomer protein exhibits Fc IgG binding ability. We report here a molecular mimicry between the S peplomer protein of Bovine Coronavirus (BCV) and Fc gamma R. BCV S peplomer protein which belongs to the same antigenic subgroup as MHV also binds Fc portion of rabbit IgG and is immunoprecipitated by the 2.4G2 anti-Fc gamma R mab. In contrast, Transmissible Gastroenteritis Coronavirus (TGEV) and Infectious Bronchitis Virus (IBV) S peplomer proteins which represent two distinct antigenic subgroups of Coronaviridae do not bind rabbit IgG and do not react with anti-Fc gamma R mab. However, homologous swine IgG, but not its F(ab')2 fragments, immunoprecipitated from TGEV-infected cells a polypeptide chain with molecular mass of 195 kDa, identical to that immunoprecipitated by the T36 mab anti-TGEV S peplomer protein.

Rabbits

Coronavirus - classification

Membrane Glycoproteins - metabolism

Infectious bronchitis virus - chemistry

Rats

Transmissible gastroenteritis virus - chemistry

Coronavirus, Bovine - chemistry

Receptors, IgG - metabolism

Spike Glycoprotein, Coronavirus

Murine hepatitis virus - chemistry

Animals

Coronavirus - chemistry

Viral Envelope Proteins - metabolism

Protein Binding

Mice

Antibodies, Monoclonal - metabolism

Immunoglobulin Fab Fragments - immunology

Antibodies, Monoclonal - immunology

Immunoglobulin G - metabolism

Details

Title: Subtitle: Molecular mimicry between S peplomer proteins of coronaviruses (MHV, BCV, TGEV and IBV) and Fc receptor
Creators: E L Oleszak - Department of Pathology and Laboratory Medicine, University of Texas Health Science Center Medical School at Houston
S Perlman
R Parr
E W Collisson
J L Leibowitz
Resource Type: Journal article
Publication Details: Advances in experimental medicine and biology, Vol.342, pp.183-188
DOI: 10.1007/978-1-4615-2996-5_29
PMID: 8209728
NLM abbreviation: Adv Exp Med Biol
ISSN: 0065-2598
Publisher: United States
Language: English
Date published: 1993
Academic Unit: Microbiology and Immunology; Stead Family Department of Pediatrics; Iowa Neuroscience Institute; Infectious Disease (Pediatrics)
Record Identifier: 9983777346402771

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