Journal article
Molecular mimicry between Zika virus and central nervous system inflammatory demyelinating disorders: the role of NS5 Zika virus epitope and PLP autoantigens
Arquivos de neuro-psiquiatria, Vol.81(4), pp.357-368
04/01/2023
DOI: 10.1055/s-0043-1768698
PMID: 37160141
Abstract
Evidence indicates a strong link between Zika virus (ZikV) and neurological complications. Acute myelitis, optic neuritis, polyneuropathy, and encephalomyelitis that mimic inflammatory idiopathic demyelination disorders (IIDD) after ZikV infection have been reported in Brazil.
The present study aims to investigate the possible occurrence of molecular mimicry between ZikV antigens and Multiple Sclerosis (MS) autoantigens, the most frequent IIDD of the central nervous system (CNS).
A retrospective cohort study with 305 patients admitted due to suspected arbovirus infection in Rio de Janeiro was performed, all subjects were submitted to neurological examination, and a biological sample was collected for serologic and molecular diagnostic. Bioinformatics tools were used to analyze the peptides shared between ZikV antigens and MS autoantigens.
Of 305 patients, twenty-six were positive for ZikV and 4 presented IDD patterns found in MS cases. Sequence homology comparisons by bioinformatics approach between NS5 ZikV and PLP MS protein revealed a homology of 5/6 consecutive amino acids (CSSVPV/CSAVPV) with 83% identity, deducing a molecular mimicry. Analysis of the 3D structures revealed a similar conformation with alpha helix presentation.
Molecular mimicry between NS5 Zika virus antigen and PLP MS autoantigens emerge as a possible mechanism for IDD spectrum in genetically susceptible individuals.
Details
- Title: Subtitle
- Molecular mimicry between Zika virus and central nervous system inflammatory demyelinating disorders: the role of NS5 Zika virus epitope and PLP autoantigens
- Creators
- Laise Carolina França - Universidade Federal do Estado do Rio de JaneiroFabrícia Lima Fontes-Dantas - Universidade do Estado do Rio de JaneiroDiogo Gomes Garcia - Universidade Federal do Estado do Rio de JaneiroAmanda Dutra de Araújo - Universidade Federal do Estado do Rio de JaneiroJoão Paulo da Costa Gonçalves - Universidade Federal do Estado do Rio de JaneiroCláudia Cecília da Silva Rêgo - Universidade Federal do Estado do Rio de JaneiroElielson Veloso da Silva - Universidade Federal do Estado do Rio de JaneiroOsvaldo José Moreira do Nascimento - Hospital Universitário Antônio PedroFernanda Cristina Rueda Lopes - Hospital Universitário Antônio PedroAlice Laschuk Herlinger - Hospital Universitário Antônio PedroRenato Santana de Aguiar - Hospital Universitário Antônio PedroOrlando da Costa Ferreira Junior - Universidade Federal do Rio de JaneiroFernando Faria Andrade Figueira - Hospital São Vicente de PauloJorge Paes Barreto Marcondes de Souza - Hospital Universitário Clementino Fraga FilhoJoelma Freire De Mesquita - Universidade do Estado do Rio de JaneiroSoniza Vieira Alves-Leon - Hospital Universitário Clementino Fraga Filho
- Resource Type
- Journal article
- Publication Details
- Arquivos de neuro-psiquiatria, Vol.81(4), pp.357-368
- DOI
- 10.1055/s-0043-1768698
- PMID
- 37160141
- NLM abbreviation
- Arq Neuropsiquiatr
- ISSN
- 0004-282X
- eISSN
- 1678-4227
- Alternative title
- Mimetismo molecular entre o vírus Zika e os distúrbios inflamatórios desmielinizantes do sistema nervoso central: o papel do epítopo NS5 do vírus Zika e dos autoantígenos PLP
- Language
- English
- Date published
- 04/01/2023
- Academic Unit
- Neurology
- Record Identifier
- 9985182279902771
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