Journal article
Molecular mimicry of a carbohydrate epitope on a major surface glycoprotein of Trypanosoma cruzi by using anti-idiotypic antibodies
The Journal of immunology (1950), Vol.135(6), pp.4155-4159
1985
DOI: 10.4049/jimmunol.135.6.4155
PMID: 2415602
Abstract
The use of anti-idiotypic antibodies (Ab2) to induce anti-microbial immunity might be particularly advantageous with respect to responses directed against carbohydrate determinants, because it may not be feasible to reproduce these epitopes by recombinant DNA technology. In the present studies, rabbit Ab2 were produced against a recurrent BALB/c idiotype defined by a monoclonal antibody (WIC 29.26) with specificity for a carbohydrate epitope of a major surface glycoprotein of Trypanosoma cruzi. The Ab2 induced specific antibodies in mice, rabbits, and guinea pigs, and reacted with parasite-induced anti-T. cruzi antibodies from mice and rabbits as well as humans. The behavior of this Ab2 is therefore consistent with that of the antigen itself, and suggests that molecular mimicry of carbohydrate epitopes can be easily achieved.
Details
- Title: Subtitle
- Molecular mimicry of a carbohydrate epitope on a major surface glycoprotein of Trypanosoma cruzi by using anti-idiotypic antibodies
- Creators
- David L Sacks - NIH, national inst. allergy infectious diseasesLouis V Kirchhoff - NIH, national inst. allergy infectious diseasesSara Hieny - NIH, national inst. allergy infectious diseasesAlan Sher - NIH, national inst. allergy infectious diseases
- Resource Type
- Journal article
- Publication Details
- The Journal of immunology (1950), Vol.135(6), pp.4155-4159
- DOI
- 10.4049/jimmunol.135.6.4155
- PMID
- 2415602
- NLM abbreviation
- J Immunol
- ISSN
- 0022-1767
- eISSN
- 1550-6606
- Publisher
- American Association of Immunologists
- Language
- English
- Date published
- 1985
- Academic Unit
- Psychiatry; Infectious Diseases; Epidemiology; Internal Medicine
- Record Identifier
- 9984280877102771
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