Journal article
Molecular pathogenesis of the obligate intracellular bacterium Coxiella burnetii
Nature reviews. Microbiology, Vol.11(8), pp.561-573
08/2013
DOI: 10.1038/nrmicro3049
PMCID: PMC4134018
PMID: 23797173
Abstract
The agent of Q fever,
Coxiella burnetii,
is an obligate intracellular bacterium that causes acute and chronic infections. The study of
C. burnetii
pathogenesis has benefited from two recent fundamental advances: improved genetic tools and the ability to grow the bacterium in extracellular media. In this Review, we describe how these recent advances have improved our understanding of
C. burnetii
invasion and host cell modulation, including the formation of replication-permissive
Coxiella
-containing vacuoles. Furthermore, we describe the Dot/Icm (defect in organelle trafficking/intracellular multiplication) system, which is used by
C. burnetii
to secrete a range of effector proteins into the host cell, and we discuss the role of these effectors in remodelling the host cell.
Details
- Title: Subtitle
- Molecular pathogenesis of the obligate intracellular bacterium Coxiella burnetii
- Creators
- Erin J van Schaik - Department of Microbial and Molecular Pathogenesis, Texas A&M Health Science Center College of Medicine, Bryan, Texas 77807–3260, USAChen Chen - Department of Microbial and Molecular Pathogenesis, Texas A&M Health Science Center College of Medicine, Bryan, Texas 77807–3260, USAKatja Mertens - Department of Microbial and Molecular Pathogenesis, Texas A&M Health Science Center College of Medicine, Bryan, Texas 77807–3260, USAMary M Weber - Department of Microbial and Molecular Pathogenesis, Texas A&M Health Science Center College of Medicine, Bryan, Texas 77807–3260, USAJames E Samuel - Department of Microbial and Molecular Pathogenesis, Texas A&M Health Science Center College of Medicine, Bryan, Texas 77807–3260, USA
- Resource Type
- Journal article
- Publication Details
- Nature reviews. Microbiology, Vol.11(8), pp.561-573
- DOI
- 10.1038/nrmicro3049
- PMID
- 23797173
- PMCID
- PMC4134018
- NLM abbreviation
- Nat Rev Microbiol
- ISSN
- 1740-1526
- eISSN
- 1740-1534
- Publisher
- Springer Science and Business Media LLC
- Language
- English
- Date published
- 08/2013
- Academic Unit
- Molecular Physiology and Biophysics; Microbiology and Immunology
- Record Identifier
- 9984083274502771
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