Molecular processes that drive cigarette smoke-induced epithelial cell fate of the lung

Toru Nyunoya; Yohannes Mebratu; Amelia Contreras; Monica Delgado; Hitendra S Chand; Yohannes Tesfaigzi

doi:10.1165/rcmb.2013-0348TR

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Molecular processes that drive cigarette smoke-induced epithelial cell fate of the lung

Journal article

Peer reviewed

Molecular processes that drive cigarette smoke-induced epithelial cell fate of the lung

Toru Nyunoya, Yohannes Mebratu, Amelia Contreras, Monica Delgado, Hitendra S Chand and Yohannes Tesfaigzi

American journal of respiratory cell and molecular biology, Vol.50(3), pp.471-482

03/01/2014

DOI: 10.1165/rcmb.2013-0348TR

PMID: 24111585

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Abstract

Cigarette smoke contains numerous chemical compounds, including abundant reactive oxygen/nitrogen species and aldehydes, and many other carcinogens. Long-term cigarette smoking significantly increases the risk of various lung diseases, including chronic obstructive pulmonary disease and lung cancer, and contributes to premature death. Many in vitro and in vivo studies have elucidated mechanisms involved in cigarette smoke-induced inflammation, DNA damage, and autophagy, and the subsequent cell fates, including cell death, cellular senescence, and transformation. In this Translational Review, we summarize the known pathways underlying these processes in airway epithelial cells to help reveal future challenges and describe possible directions of research that could lead to better management and treatment of these diseases.

Animals

Cell Death

Cellular Senescence

DNA Damage

Epithelial Cells - drug effects

Epithelial Cells - metabolism

Epithelial Cells - pathology

Humans

Inflammation Mediators - metabolism

Lung Diseases - etiology

Lung Diseases - metabolism

Lung Diseases - pathology

Prognosis

Respiratory Mucosa - drug effects

Respiratory Mucosa - metabolism

Respiratory Mucosa - pathology

Risk Factors

Signal Transduction - drug effects

Smoke - adverse effects

Smoking - adverse effects

Details

Title: Subtitle: Molecular processes that drive cigarette smoke-induced epithelial cell fate of the lung
Creators: Toru Nyunoya - Lovelace Respiratory Research Institute
Yohannes Mebratu - Lovelace Respiratory Research Institute
Amelia Contreras - Lovelace Respiratory Research Institute
Monica Delgado - Lovelace Respiratory Research Institute
Hitendra S Chand - Lovelace Respiratory Research Institute
Yohannes Tesfaigzi - Lovelace Respiratory Research Institute
Resource Type: Journal article
Publication Details: American journal of respiratory cell and molecular biology, Vol.50(3), pp.471-482
DOI: 10.1165/rcmb.2013-0348TR
PMID: 24111585
ISSN: 1044-1549
eISSN: 1535-4989
Grant note: R03 AG037768 / NIA NIH HHS UL1 TR001449 / NCATS NIH HHS R01 ES015482 / NIEHS NIH HHS UL1 TR000041 / NCATS NIH HHS HL068111 / NHLBI NIH HHS R01 HL068111 / NHLBI NIH HHS R56 HL068111 / NHLBI NIH HHS AG037768 / NIA NIH HHS ES015482 / NIEHS NIH HHS
Language: English
Date published: 03/01/2014
Academic Unit: Internal Medicine
Record Identifier: 9985214170202771

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