Journal article
Molecular requirements for T cell activation by the staphylococcal toxic shock syndrome toxin-1
The Journal of immunology (1950), Vol.144(6), pp.2089-2095
03/15/1990
DOI: 10.4049/jimmunol.144.6.2089
PMID: 2313089
Abstract
The activation of Ag-specific, Ia molecule-restricted, TCR V beta 3+ T cell clones by staphylococcal toxic shock syndrome toxin-1 (TSST-1), was investigated. The results show that although Ag- and TSST-1-induced activation of T cell clones both require TCR expression and similar biologic activation signals, the Ia molecule requirement for TSST-1 recognition was much less stringent than that observed for antigenic peptide recognition. In addition, T cell clones recognized TSST-1 without processing by APC. These results suggest that the ability of TSST-1 to polyclonally activate T cells is dependent on TCR recognition of the intact toxin molecule bound to a nonpolymorphic region(s) of the Ia molecule resulting in the same activation events induced by Ag recognition.
Details
- Title: Subtitle
- Molecular requirements for T cell activation by the staphylococcal toxic shock syndrome toxin-1
- Creators
- Steven D Norton - Department of Microbiology, University of Minnesota Medical School, Minneapolis 55455Patrick M SchlievertRichard P NovickMarc K Jenkins
- Resource Type
- Journal article
- Publication Details
- The Journal of immunology (1950), Vol.144(6), pp.2089-2095
- Publisher
- United States
- DOI
- 10.4049/jimmunol.144.6.2089
- PMID
- 2313089
- ISSN
- 0022-1767
- eISSN
- 1550-6606
- Grant note
- AI-27998 / NIAID NIH HHS AI-22159 / NIAID NIH HHS
- Language
- English
- Date published
- 03/15/1990
- Academic Unit
- Microbiology and Immunology; Internal Medicine
- Record Identifier
- 9984001157502771
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