Molecular typing of antibiotic-resistant Staphylococcus aureus in Nigeria

S.M O’Malley; F.E Emele; F.O Nwaokorie; N Idika; A.K Umeizudike; I Emeka-Nwabunnia; B.M Hanson; R Nair; S.E Wardyn; T.C Smith

doi:10.1016/j.jiph.2014.08.001

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Molecular typing of antibiotic-resistant Staphylococcus aureus in Nigeria

Journal article

Open access

Peer reviewed

Molecular typing of antibiotic-resistant Staphylococcus aureus in Nigeria

S.M O’Malley, F.E Emele, F.O Nwaokorie, N Idika, A.K Umeizudike, I Emeka-Nwabunnia, B.M Hanson, R Nair, S.E Wardyn and T.C Smith

Journal of infection and public health, Vol.8(2), pp.187-193

03/2015

DOI: 10.1016/j.jiph.2014.08.001

PMID: 25441090

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Abstract

Antibiotic-resistant Staphylococcus aureus including methicillin-resistant strains (MRSA) are a major concern in densely populated urban areas. Initial studies of S. aureus in Nigeria indicated existence of antibiotic-resistant S. aureus strains in clinical and community settings. 73 biological samples (40 throat, 23 nasal, 10 wound) were collected from patients and healthcare workers in three populations in Nigeria: Lagos University Teaching Hospital, Nigerian Institute of Medical Research, and Owerri General Hospital. S. aureus was isolated from 38 of 73 samples (52%). Of the 38 S. aureus samples, 9 (24%) carried the Panton-Valentine leukocidin gene (PVL) while 16 (42%) possessed methicillin resistance genes (mecA). Antibiotic susceptibility profiles indicated resistance to several broad-spectrum antibiotics. Antibiotic-resistant S. aureus isolates were recovered from clinical and community settings in Nigeria. Insight about S. aureus in Nigeria may be used to improve antibiotic prescription methods and minimize the spread of antibiotic-resistant organisms in highly populated urban communities similar to Lagos, Nigeria.

spa typing

mecA

Antibiotic resistance

PVL

Nigeria

Epidemiology

Staphylococcus aureus

Details

Title: Subtitle: Molecular typing of antibiotic-resistant Staphylococcus aureus in Nigeria
Creators: S.M O’Malley - Center for Emerging Infectious Diseases, College of Public Health, University of Iowa, United States
F.E Emele - Department of Medical Microbiology, Nnamdi Azikiwe University, Nigeria
F.O Nwaokorie - Nigerian Institute of Medical Research, Nigeria
N Idika - Nigerian Institute of Medical Research, Nigeria
A.K Umeizudike - Lagos University Teaching Hospital, Nigeria
I Emeka-Nwabunnia - Department of Biotechnology, Federal University of Technology, Owerri, Nigeria
B.M Hanson - Center for Emerging Infectious Diseases, College of Public Health, University of Iowa, United States
R Nair - Center for Emerging Infectious Diseases, College of Public Health, University of Iowa, United States
S.E Wardyn - Center for Emerging Infectious Diseases, College of Public Health, University of Iowa, United States
T.C Smith - Department of Biostatistics, Environmental Health Sciences, & Epidemiology, College of Public Health, Kent State University, United States
Resource Type: Journal article
Publication Details: Journal of infection and public health, Vol.8(2), pp.187-193
DOI: 10.1016/j.jiph.2014.08.001
PMID: 25441090
NLM abbreviation: J Infect Public Health
ISSN: 1876-0341
eISSN: 1876-035X
Publisher: Elsevier Ltd
Language: English
Date published: 03/2015
Academic Unit: Epidemiology; General Internal Medicine; Otolaryngology; Internal Medicine
Record Identifier: 9984094397902771

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