Monitoring of motor action potentials after stimulation of the spinal cord

M MACHIDA; S. L WEINSTEIN; T YAMADA; J KIMURA; T ITAGAKI; T USUI

doi:10.2106/00004623-198870060-00016

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Monitoring of motor action potentials after stimulation of the spinal cord

Journal article

Peer reviewed

Monitoring of motor action potentials after stimulation of the spinal cord

M MACHIDA, S. L WEINSTEIN, T YAMADA, J KIMURA, T ITAGAKI and T USUI

Journal of bone and joint surgery. American volume, Vol.70(6), pp.911-918

1988

DOI: 10.2106/00004623-198870060-00016

PMID: 3392089

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Abstract

We recorded motor action potentials in cats, using surface electrodes placed over the soleus muscle. The action potentials were generated by stimulating the spinal cord with electrodes in the epidural space at the level of the fifth or sixth thoracic vertebra. This also was done in humans, using the same methods of stimulating and recording, but the intensity of the stimulus was adjusted to produce little or no twitch of the paraspinal muscles. In the animal experiment, the motor action potential was abolished after transection of the pyramidal tract and was progressively attenuated with effective doses of a curare-like agent. We also tested the effect of distraction, using the same technique as is used in Harrington instrumentation, and found that the amount of distraction that caused reduction of the amplitude of the motor action potential of more than 50 per cent, when sustained for longer than seven minutes, caused permanent paraplegia in two cats. The evaluation of spinal evoked potentials that were obtained from epidural electrodes placed caudad to the level of distraction, and of motor action potentials that were recorded over the soleus muscle, following the same stimulus, showed a similar pattern of reduction after distraction in five of seven cats. The other two cats had irreversible reduction of motor action potential associated with unchanged spinal evoked potential, and both cats became paraplegic.(ABSTRACT TRUNCATED AT 250 WORDS)

Neurology

Biological and medical sciences

Medical sciences

Nervous system involvement in other diseases. Miscellaneous

Details

Title: Subtitle: Monitoring of motor action potentials after stimulation of the spinal cord
Creators: M MACHIDA - Nihon univ. school medicine, dep. orthopaedic surgery, Tokyo, Japan
S. L WEINSTEIN - Nihon univ. school medicine, dep. orthopaedic surgery, Tokyo, Japan
T YAMADA - Nihon univ. school medicine, dep. orthopaedic surgery, Tokyo, Japan
J KIMURA - Nihon univ. school medicine, dep. orthopaedic surgery, Tokyo, Japan
T ITAGAKI - Nihon univ. school medicine, dep. orthopaedic surgery, Tokyo, Japan
T USUI - Nihon univ. school medicine, dep. orthopaedic surgery, Tokyo, Japan
Resource Type: Journal article
Publication Details: Journal of bone and joint surgery. American volume, Vol.70(6), pp.911-918
DOI: 10.2106/00004623-198870060-00016
PMID: 3392089
NLM abbreviation: J Bone Joint Surg Am
ISSN: 0021-9355
eISSN: 1535-1386
Publisher: Journal of Bone and Joint Surgery Incorporated; Boston, MA
Language: English
Date published: 1988
Academic Unit: Neurology; Stead Family Department of Pediatrics; Orthopedics and Rehabilitation
Record Identifier: 9984040249702771

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