Monoclonal IgM with unique specificity to gangliosides GM1 and GD1b and to lacto-N-tetraose associated with human motor neuron disease

N LATOV; A. P HAYS; H. S GREENBERG; J. W ALBERS; A. G ALESSI; D KEREN; R. K YU; L. P ROWLAND; E. A KABAT; P. D DONOFRIO; J LIAO; S MCGINNIS; K MANOUSSOS; L FREDDO; M. E SHY; W. H SHERMAN; H. W CHANG

doi:10.1212/WNL.38.5.763

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Monoclonal IgM with unique specificity to gangliosides GM1 and GD1b and to lacto-N-tetraose associated with human motor neuron disease

Journal article

Peer reviewed

Monoclonal IgM with unique specificity to gangliosides GM1 and GD1b and to lacto-N-tetraose associated with human motor neuron disease

N LATOV, A. P HAYS, H. S GREENBERG, J. W ALBERS, A. G ALESSI, D KEREN, R. K YU, L. P ROWLAND, E. A KABAT, P. D DONOFRIO, …

Neurology, Vol.38(5), pp.763-768

1988

DOI: 10.1212/WNL.38.5.763

PMID: 2452383

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Abstract

IgM lambda monoclonal antibodies in two patients with motor neuron disease showed the same unique antigenic specificity. They bound to gangliosides GM1 and GD1b and to lacto-N-tetraose-BSA. By immunofluorescence microscopy they bound to central and peripheral nerve tissue and to motor end-plates at the neuromuscular junction. Sera from control subjects did not contain antibodies of similar specificity. Monoclonal IgMs with the same unique specificity could be responsible for motor neuron disease in some patients with monoclonal gammopathies.

Neurology

Biological and medical sciences

Medical sciences

Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases

Details

Title: Subtitle: Monoclonal IgM with unique specificity to gangliosides GM1 and GD1b and to lacto-N-tetraose associated with human motor neuron disease
Creators: N LATOV - Columbia univ., coll. physicians surgeons, New York NY 10032, United States
A. P HAYS - Columbia univ., coll. physicians surgeons, New York NY 10032, United States
H. S GREENBERG - Columbia univ., coll. physicians surgeons, New York NY 10032, United States
J. W ALBERS - Columbia univ., coll. physicians surgeons, New York NY 10032, United States
A. G ALESSI - Columbia univ., coll. physicians surgeons, New York NY 10032, United States
D KEREN - Columbia univ., coll. physicians surgeons, New York NY 10032, United States
R. K YU - Columbia univ., coll. physicians surgeons, New York NY 10032, United States
L. P ROWLAND - Columbia univ., coll. physicians surgeons, New York NY 10032, United States
E. A KABAT - Columbia univ., coll. physicians surgeons, New York NY 10032, United States
P. D DONOFRIO - Columbia univ., coll. physicians surgeons, New York NY 10032, United States
J LIAO - Columbia univ., coll. physicians surgeons, New York NY 10032, United States
S MCGINNIS - Columbia univ., coll. physicians surgeons, New York NY 10032, United States
K MANOUSSOS - Columbia univ., coll. physicians surgeons, New York NY 10032, United States
L FREDDO - Columbia univ., coll. physicians surgeons, New York NY 10032, United States
M. E SHY - Columbia univ., coll. physicians surgeons, New York NY 10032, United States
W. H SHERMAN - Columbia univ., coll. physicians surgeons, New York NY 10032, United States
H. W CHANG - Columbia univ., coll. physicians surgeons, New York NY 10032, United States
Resource Type: Journal article
Publication Details: Neurology, Vol.38(5), pp.763-768
Publisher: Lippincott Williams & Wilkins; Hagerstown, MD
DOI: 10.1212/WNL.38.5.763
PMID: 2452383
ISSN: 0028-3878
eISSN: 1526-632X
Language: English
Date published: 1988
Academic Unit: Neurology; Molecular Physiology and Biophysics; Stead Family Department of Pediatrics; Iowa Neuroscience Institute
Record Identifier: 9984020622302771

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