Journal article
Monoclonal Origin of Multicentric Kaposi's Sarcoma Lesions
The New England journal of medicine, Vol.336(14), pp.988-993
04/03/1997
DOI: 10.1056/NEJM199704033361403
PMID: 9077377
Abstract
Kaposi's sarcoma is the most common tumor in patients with the acquired immunodeficiency syndrome (AIDS).
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,
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The lesions associated with the disease have four characteristic components: thin-walled neovascular formations, extravasated red cells, inflammatory lymphocytes, and proliferating spindle cells. The spindle cells, which may be the primary abnormality, are more prominent in nodular tumors than in plaque or patch lesions. Although their origin is unknown, spindle cells have the characteristic immunohistochemical and ultrastructural features of endothelial cells.
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The neoplastic or hyperplastic nature of spindle cells has long been debated,
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,
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but the demonstration that individual Kaposi's sarcoma lesions are clonal . . .
Details
- Title: Subtitle
- Monoclonal Origin of Multicentric Kaposi's Sarcoma Lesions
- Creators
- Charles S RabkinSiegfried JanzAlex LashAllen E ColemanElizabeth MusabaLance LiottaRobert J BiggarZhengping Zhuang
- Resource Type
- Journal article
- Publication Details
- The New England journal of medicine, Vol.336(14), pp.988-993
- Publisher
- Massachusetts Medical Society
- DOI
- 10.1056/NEJM199704033361403
- PMID
- 9077377
- ISSN
- 0028-4793
- eISSN
- 1533-4406
- Language
- English
- Date published
- 04/03/1997
- Academic Unit
- Pathology
- Record Identifier
- 9984083999502771
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