Monocyte Distribution Width (MDW) in Patients with COVID-19: An Indicator of Disease Severity

Praveen Sharma; Shano Naseem; Neelam Varma; Niranjan Khaire; Nishant Jindal; Abhishek Sharma; Brijesh Verma; Pankaj Malhotra; Sandhya Bastian; Elena Sukhacheva

doi:10.1007/s12288-023-01665-y

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Monocyte Distribution Width (MDW) in Patients with COVID-19: An Indicator of Disease Severity

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Monocyte Distribution Width (MDW) in Patients with COVID-19: An Indicator of Disease Severity

Praveen Sharma, Shano Naseem, Neelam Varma, Niranjan Khaire, Nishant Jindal, Abhishek Sharma, Brijesh Verma, Pankaj Malhotra, Sandhya Bastian and Elena Sukhacheva

Indian journal of hematology & blood transfusion, Vol.40(1), pp.1-5

01/01/2024

DOI: 10.1007/s12288-023-01665-y

PMCID: PMC10199660

PMID: 37362403

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Abstract

Identifying patients with Coronavirus disease-2019 (COVID-19) who may have a severe illness is essential for timely intervention and decreasing the fatality rate. In the present study, we evaluated the performance of Monocyte Distribution Width (MDW) as a prognostic marker for identifying disease severity in COVID-19 patients. We included 145 patients with PCR-confirmed COVID-19 infection in the study. The performance of MDW was evaluated by calculating the area under the receiver operating characteristic curve (AUC), specificity, sensitivity, negative predictive value, and positive predictive value. Further analysis was conducted for the disease outcome, comparing COVID-19 patients discharged (n = 135) to deceased COVID-19 patients (n = 10). As a marker of disease severity, MDW demonstrated an AUC of 0.702 (95% CI 0.620–0.775) in ROC analysis. If MDW is considered a marker of patient outcome, AUC was 0.916 (95% CI 0.862–0.953), comparing deceased COVID-19 patients vs. those who survived. At a cut-off of > 25.4 on admission, MDW correlates well with poor disease outcomes in COVID-19 patients. MDW can be considered a helpful parameter in predicting the severity of COVID-19 disease and patient outcomes. Its role and incorporation in the standard diagnostic algorithm and management of COVID-19 patients need further validation.

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Title: Subtitle: Monocyte Distribution Width (MDW) in Patients with COVID-19: An Indicator of Disease Severity
Creators: Praveen Sharma - Chandigarh, 160012 India
Shano Naseem - Post Graduate Institute of Medical Education and Research
Neelam Varma - Post Graduate Institute of Medical Education and Research
Niranjan Khaire - Post Graduate Institute of Medical Education and Research
Nishant Jindal - Post Graduate Institute of Medical Education and Research
Abhishek Sharma - Post Graduate Institute of Medical Education and Research
Brijesh Verma - Post Graduate Institute of Medical Education and Research
Pankaj Malhotra - Post Graduate Institute of Medical Education and Research
Sandhya Bastian - Beckman Coulter India Pvt. Ltd, Mumbai, India
Elena Sukhacheva - Beckman Coulter Eurocenter, Nyon, Switzerland
Resource Type: Journal article
Publication Details: Indian journal of hematology & blood transfusion, Vol.40(1), pp.1-5
DOI: 10.1007/s12288-023-01665-y
PMID: 37362403
PMCID: PMC10199660
ISSN: 0971-4502
eISSN: 0971-4502
Publisher: Springer India
Number of pages: 5
Grant note: ;
Language: English
Date published: 01/01/2024
Academic Unit: Internal Medicine
Record Identifier: 9985237503602771

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