Monocyte activation in congestive heart failure due to coronary artery disease and idiopathic dilated cardiomyopathy

S Vonhof; B Brost; M Stille-Siegener; I M Grumbach; H Kreuzer; H R Figulla

doi:10.1016/S0167-5273(97)00332-X

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Monocyte activation in congestive heart failure due to coronary artery disease and idiopathic dilated cardiomyopathy

Journal article

Peer reviewed

Monocyte activation in congestive heart failure due to coronary artery disease and idiopathic dilated cardiomyopathy

S Vonhof, B Brost, M Stille-Siegener, I M Grumbach, H Kreuzer and H R Figulla

International journal of cardiology, Vol.63(3), pp.237-244

02/28/1998

DOI: 10.1016/S0167-5273(97)00332-X

PMID: 9578350

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Abstract

To investigate plasma tumor necrosis factor (TNF)alpha, tumor necrosis factor alpha soluble receptor I, interleukin-1beta and neopterin concentrations as markers of monocyte activation in patients with heart failure. The group consisted of patients with heart failure due to dilated cardiomyopathy (n=19) and coronary artery disease (n=11). Patients without cardiac failure served as controls (n=10). TNFalpha concentrations were elevated only in heart failure patients with coronary artery disease (2.9+/-0.3 pg/ml versus 1.7+/-0.3 pg/ml; P<0.05). When the patients were grouped according to acute and chronic failure, TNFalpha concentrations were significantly elevated in acute failure (3.1+/-0.4 pg/ml, n=6 versus 1.7+/-0.2 pg/ml, n=8; P<0.05). TNFalpha concentrations were elevated in patients with coronary artery disease and chronic heart failure compared to coronary artery disease patients without failure (2.0+/-0.4 pg/ml, n=6 versus 1.8+/-0.3 pg/ml, n=7; P<0.05). A higher proportion of patients with myocardial insufficiency showed increased lipopolysaccharide-inducible TNFalpha concentrations (10/30 versus 0/9, P<0.05). TNFalpha is elevated in patients with acute cardiac decompensation. Among patients with chronic heart failure only those with coronary artery disease exhibit increased levels. Cytokine concentrations are similar in heart failure due to dilated cardiomyopathy and coronary artery disease. Monocytes of patients suffering from cardiac insufficiency show an increased sensitivity towards stimuli such as lipopolysaccharides.

Coronary Disease - blood

Cardiomyopathy, Dilated - complications

Interleukin-1 - analysis

Cardiomyopathy, Dilated - blood

Humans

Middle Aged

Heart Failure - physiopathology

Heart Failure - blood

Tumor Necrosis Factor-alpha - analysis

Receptors, Tumor Necrosis Factor - blood

Biomarkers

Hemodynamics

Monocytes - physiology

Heart Failure - etiology

Details

Title: Subtitle: Monocyte activation in congestive heart failure due to coronary artery disease and idiopathic dilated cardiomyopathy
Creators: S Vonhof - Department of Cardiology and Pulmonology, Georg-August-Universität Göttingen, Germany
B Brost
M Stille-Siegener
I M Grumbach
H Kreuzer
H R Figulla
Resource Type: Journal article
Publication Details: International journal of cardiology, Vol.63(3), pp.237-244
DOI: 10.1016/S0167-5273(97)00332-X
PMID: 9578350
NLM abbreviation: Int J Cardiol
ISSN: 0167-5273
eISSN: 1874-1754
Language: English
Date published: 02/28/1998
Academic Unit: Cardiovascular Medicine; Radiation Oncology; Internal Medicine
Record Identifier: 9984094772402771

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