Journal article
Monocytosis and a Low Lymphocyte to Monocyte Ratio Are Effective Biomarkers of Ulcerative Colitis Disease Activity
Inflammatory bowel diseases, Vol.21(8), pp.1769-1775
08/2015
DOI: 10.1097/MIB.0000000000000427
PMCID: PMC5193095
PMID: 25993688
Abstract
Current biomarkers in ulcerative colitis (UC) are limited by their performance, cost, and limited availability in daily practice. This study examined alterations in the leukocyte profiles as biomarkers of UC activity, including the effects of age, gender, and medications.
Case-control study that included 110 UC subjects, 75 subjects with Clostridium difficile infection, and 75 non-inflammatory bowel disease (IBD) subjects, randomly selected from a single-institution IBD database. Mean values of neutrophils (N), lymphocytes (L), monocytes (M) and their ratios were compared between groups. Receiver operator curve analyses assessed the performance of each biomarker in discriminating disease states. Subgroup analyses examined leukocytes profiles with endoscopic activity.
Elevated monocyte counts and decreased L/M values significantly differed between subjects with active UC and UC in remission and performed better than the other leukocyte profiles. A monocyte count of 483 and L/M ratio of 3.1 were 60% sensitive and had a specificity of 61% and 53%, respectively for active UC. Monocyte count >860 and L/M value <1.6 had a 75% positive predictive value for UC activity. Those markers also correlated with endoscopically active disease. L/M and N/L values performed best at differentiating active UC from non-IBD controls, whereas N/L and N values performed best at differentiating from C. difficile controls.
Monocytosis and a low L/M ratio might be effective, readily available, and low-cost biomarkers to identify disease activity in UC patients. N/L values were more effective in distinguishing active UC patients from patients without IBD and those with C. difficile infection.
Details
- Title: Subtitle
- Monocytosis and a Low Lymphocyte to Monocyte Ratio Are Effective Biomarkers of Ulcerative Colitis Disease Activity
- Creators
- Cynthia E Cherfane - Department of Internal Medicine, University of Iowa Roy J. and Lucille A. Carver College of Medicine, Iowa City, Iowa; †Department of Internal Medicine, University of New Mexico School of Medicine, Albuquerque, New Mexico; and ‡Department of Biostatistics, College of Public Health, University of Iowa, Iowa City, IowaLuke GesselDominic CirilloMiriam B ZimmermanSteven Polyak
- Resource Type
- Journal article
- Publication Details
- Inflammatory bowel diseases, Vol.21(8), pp.1769-1775
- Publisher
- England
- DOI
- 10.1097/MIB.0000000000000427
- PMID
- 25993688
- PMCID
- PMC5193095
- ISSN
- 1078-0998
- eISSN
- 1536-4844
- Grant note
- UL1 TR000442 / NCATS NIH HHS 2 UL1 TR000442 / NCATS NIH HHS
- Language
- English
- Date published
- 08/2015
- Academic Unit
- Epidemiology; Biostatistics; Internal Medicine
- Record Identifier
- 9983997449102771
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