Journal article
Monovalent SARS-CoV-2 mRNA vaccine does not boost Omicron-specific immune response in diabetic and control pediatric patients
The Journal of infectious diseases, Vol.229(4), pp.1059-1067
04/12/2024
DOI: 10.1093/infdis/jiad366
PMCID: PMC11011175
PMID: 37624979
Abstract
While the immunogenicity of SARS-CoV-2 vaccines has been well described in adults, pediatric populations have been less studied. In particular, children with type 1 diabetes are generally at elevated risk for more severe disease after infections, but are understudied in terms of COVID-19 and SARS-CoV-2 vaccine responses. We investigated the immunogenicity of COVID-19 mRNA vaccinations in 35 children with type 1 diabetes (T1D) and 23 controls and found that these children develop levels of SARS-CoV-2 neutralizing antibody titers and spike protein-specific T cells comparable to non-diabetic children. However, in comparing the neutralizing antibody responses in children who received two doses of mRNA vaccines (24 T1D; 14 controls) with those who received a third, booster dose (11 T1D; 9 controls), we found that the booster dose increased neutralizing antibody titers against ancestral SARS-CoV-2 strains but, unexpectedly, not omicron lineage variants. In contrast, boosting enhanced omicron variant neutralizing antibody titers in adults.
Details
- Title: Subtitle
- Monovalent SARS-CoV-2 mRNA vaccine does not boost Omicron-specific immune response in diabetic and control pediatric patients
- Creators
- Alan Sariol - University of IowaMolly A Vickers - University of IowaShannon M ChristensenDaniela Weiskopf - La Jolla Institute for ImmunologyAndrew W Norris - University of IowaMichael J Tansey - Iowa Diabetes and Endocrinology Research CenterCatherina T Pinnaro - Iowa Diabetes and Endocrinology Research CenterStanley Perlman - University of Iowa
- Resource Type
- Journal article
- Publication Details
- The Journal of infectious diseases, Vol.229(4), pp.1059-1067
- DOI
- 10.1093/infdis/jiad366
- PMID
- 37624979
- PMCID
- PMC11011175
- NLM abbreviation
- J Infect Dis
- eISSN
- 1537-6613
- Publisher
- Oxford University Press (OUP)
- Grant note
- DOI: 10.13039/100000002, name: National Institutes of Health, award: P01 AI060699, R01 AI129269, RC2 DK124207, R01 DK115791, K12 HD27748, T32 AI007260
- Language
- English
- Electronic publication date
- 08/25/2023
- Date published
- 04/12/2024
- Academic Unit
- Endocrinology and Diabetes; Microbiology and Immunology; Stead Family Department of Pediatrics; Iowa Neuroscience Institute; Fraternal Order of Eagles Diabetes Research Center; Biochemistry and Molecular Biology; Infectious Disease (Pediatrics)
- Record Identifier
- 9984457698802771
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