Journal article
Montelukast and risk for antidepressant treatment failure
Journal of psychosomatic research, Vol.164, pp.111075-111075
01/01/2023
DOI: 10.1016/j.jpsychores.2022.111075
PMID: 36368225
Abstract
Objective: While implicated in causing depression, no studies have examined the impact of montelukast on an-tidepressant effectiveness. We examined whether existing montelukast therapy was associated with acute anti-depressant treatment failure (objective 1), and whether montelukast initiation was associated with depression relapse during maintenance antidepressant therapy (objective 2), relative to inhaled corticosteroid (ICS).Methods: Patients with asthma and depression were identified using national Veterans Health Administration data from 2007 to 2019. Objective 1: 12,109 patients initiated an antidepressant after receiving montelukast or ICS for 6 months. The primary outcome was acute antidepressant treatment failure, defined as subsequent initiation of a new antidepressant or augmenting agent within 6 months. Objective 2: 14,673 patients initiated montelukast or ICS after receiving stable antidepressant monotherapy for 6 months. The primary outcome of depression relapse was defined by a subsequent change in the pre-existing maintenance antidepressant regimen within 6 months. Both objectives employed a retrospective cohort design with log-binomial regression.Results: Objective 1: Acute antidepressant failure was observed in 21.3% (628/2943) and 22.3% (2044/9166) of patients receiving montelukast versus ICS, respectively. Relative risk in adjusted analyses was 0.98 (95% CI: 0.90, 1.07). Objective 2: Depression relapse was observed in 24.4% (288/1182) and 22.4% (3027/13,491) of patients initiating montelukast versus ICS, respectively. Relative risk in adjusted analyses was 1.08 (95% CI: 0.96, 1.20) within 6 months and 1.50 (95% CI: 1.16, 1.93) within 45 days.Conclusion: Discontinuation of existing montelukast therapy is unnecessary when initiating antidepressants. However, potential evidence for depression relapse following montelukast initiation warrants additional investigation.
Details
- Title: Subtitle
- Montelukast and risk for antidepressant treatment failure
- Creators
- Haemy Chung - Iowa City VA Health Care SystemKaitlin Hanken - Iowa City Vet Affairs Hlth Care Syst, Dept Pharm, Iowa City, IA USAAlicia K. Gerke - University of IowaBrian C. Lund
- Resource Type
- Journal article
- Publication Details
- Journal of psychosomatic research, Vol.164, pp.111075-111075
- Publisher
- Elsevier
- DOI
- 10.1016/j.jpsychores.2022.111075
- PMID
- 36368225
- ISSN
- 0022-3999
- eISSN
- 1879-1360
- Number of pages
- 6
- Grant note
- CIN 13-412 / Health Services Research and Development Service, Department of Veterans Affairs; US Department of Veterans Affairs Iowa City VA Health Care System, Department of Pharmacy Services
- Language
- English
- Date published
- 01/01/2023
- Academic Unit
- Pulmonary, Critical Care, and Occupational Medicine; Epidemiology; Internal Medicine
- Record Identifier
- 9984359688802771
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