Mood and cytokine response to influenza virus in older adults

Erin S Costanzo; Susan K Lutgendorf; Marian L Kohut; Nicole Nisly; Kayla Rozeboom; Shawn Spooner; JoAnn Benda; Janet E McElhaney

doi:10.1093/gerona/59.12.1328

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Mood and cytokine response to influenza virus in older adults

Journal article

Open access

Peer reviewed

Mood and cytokine response to influenza virus in older adults

Erin S Costanzo, Susan K Lutgendorf, Marian L Kohut, Nicole Nisly, Kayla Rozeboom, Shawn Spooner, JoAnn Benda and Janet E McElhaney

The journals of gerontology. Series A, Biological sciences and medical sciences, Vol.59(12), pp.1328-1333

12/2004

DOI: 10.1093/gerona/59.12.1328

PMID: 15699534

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Abstract

Previous research has indicated that older adults with severe life stress show attenuated immune responses to influenza vaccination. Associations among mood, optimism, stress, and the in vitro cytokine response to influenza virus and vaccine were evaluated in 18 healthy older adults with low to moderate life stress. Peripheral blood mononuclear cells were stimulated in cultures with 1999-2000 influenza vaccine viruses (A/Beijing/262/95, A/Sydney/5/97, and B/Yamanashi/166/98) and the 2000-2001 trivalent vaccine (containing A/New Caledonia/20/99, A/Panama/2007/99, and B/Yamanashi/166/98). The levels of T-helper type 1 (interleukin-2 and interferon-gamma) and type 2 (interleukin-10) cytokines were measured in culture supernatants. Stress, age, and current health practices were unrelated to cytokine production. Older adults reporting greater anger, fatigue, confusion, and total mood disturbance had poorer cytokine responses to live virus and vaccine stimulation. In contrast, older adults who reported greater vigor and those who were more optimistic had greater cytokine responses to both live virus and vaccine. These relationships were largely unaffected by medications or health conditions. These findings suggest that among older adults, even mild to moderate mood disturbance is associated with an attenuated cellular immune response to live influenza virus and vaccine.

Humans

Male

Th2 Cells - immunology

Th1 Cells - immunology

Orthomyxoviridae - immunology

Mood Disorders - immunology

Influenza Vaccines - immunology

Aged, 80 and over

Female

Interleukin-10 - biosynthesis

Aged

Interleukin-2 - biosynthesis

Cytokines - biosynthesis

Interferon-gamma - biosynthesis

Details

Title: Subtitle: Mood and cytokine response to influenza virus in older adults
Creators: Erin S Costanzo - University of Iowa, Iowa City, IA 52242, USA
Susan K Lutgendorf
Marian L Kohut
Nicole Nisly
Kayla Rozeboom
Shawn Spooner
JoAnn Benda
Janet E McElhaney
Resource Type: Journal article
Publication Details: The journals of gerontology. Series A, Biological sciences and medical sciences, Vol.59(12), pp.1328-1333
DOI: 10.1093/gerona/59.12.1328
PMID: 15699534
NLM abbreviation: J Gerontol A Biol Sci Med Sci
ISSN: 1079-5006
eISSN: 1758-535X
Publisher: United States
Grant note: R21 CA88293-01 / NCI NIH HHS
Language: English
Date published: 12/2004
Academic Unit: Psychological and Brain Sciences; Iowa Neuroscience Institute; Gender, Women's and Sexuality Studies; Obstetrics and Gynecology; Urology; Internal Medicine
Record Identifier: 9984002418402771

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