Journal article
More Judicious Use of Expectant Management for Localized Prostate Cancer during the Last 2 Decades
The Journal of urology, Vol.197(3), pp.614-620
03/2017
DOI: 10.1016/j.juro.2016.10.067
PMCID: PMC5315642
PMID: 27984110
Abstract
Urologists have been criticized for overtreating men with low risk prostate cancer and for passively observing older men with higher risk disease. Proponents of active surveillance for low risk disease and critics of watchful waiting for higher risk disease have advocated for more judicious use of observation. Thus, we compared 2 population based cohorts to determine how expectant management has evolved during the last 2 decades.
A total of 5,871 men with localized prostate cancer were enrolled in the PCOS (Prostate Cancer Outcomes Study) or the CEASAR (Comparative Effectiveness Analysis of Surgery and Radiation) study. We compared the use of definitive treatment vs expectant management (watchful waiting or active surveillance) across cohorts, focusing on the influence of disease risk, age and comorbidities.
Use of watchful waiting or active surveillance was similar in PCOS and CEASAR (14% in each). Compared to the PCOS, more men in the CEASAR study with low risk disease selected watchful waiting or active surveillance (25% vs 15%, respectively), whereas fewer men with intermediate (7% vs 14%) and high risk (3% vs 10%) disease chose watchful waiting or active surveillance (p <0.001 for each). The association of disease risk with watchful waiting or active surveillance was significantly larger in CEASAR than in PCOS (OR 7.3, 95% CI 3.4 to 15.7). Older age was associated with watchful waiting or active surveillance in both cohorts but there was no association between comorbidity and watchful waiting or active surveillance in the CEASAR study.
Use of watchful waiting or active surveillance was more aligned with disease risk in CEASAR compared to PCOS, suggesting there has been a pivot from watchful waiting to active surveillance. While older men were more likely to be observed, comorbidity had little, if any, influence.
Details
- Title: Subtitle
- More Judicious Use of Expectant Management for Localized Prostate Cancer during the Last 2 Decades
- Creators
- J.B. Eifler - Vanderbilt UniversityJ. Alvarez - Vanderbilt UniversityT. Koyama - Vanderbilt UniversityR.M. Conwill - Vanderbilt UniversityC.R. Ritch - University of Miami Health SystemK.E. Hoffman - The University of Texas MD Anderson Cancer CenterM.J. Resnick - Vanderbilt UniversityD.F. Penson - Vanderbilt UniversityD.A. Barocas - Vanderbilt UniversityPeter C. AlbertsenMatthew R. CooperbergMichael GoodmanSheldon GreenfieldAnn HamiltonRichard M. HoffmanSherrie H. KaplanLisa PaddockJanet L. StanfordAntoinette M. StroupXiao-Cheng WuComparative Effectiveness Analysis of Surgery and Radiation (CEASAR) Study InvestigatorsProstate Cancer Outcomes Study (PCOS) Investigators
- Resource Type
- Journal article
- Publication Details
- The Journal of urology, Vol.197(3), pp.614-620
- Publisher
- Elsevier Inc
- DOI
- 10.1016/j.juro.2016.10.067
- PMID
- 27984110
- PMCID
- PMC5315642
- ISSN
- 0022-5347
- eISSN
- 1527-3792
- Language
- English
- Date published
- 03/2017
- Academic Unit
- Epidemiology; General Internal Medicine; Internal Medicine
- Record Identifier
- 9984359844402771
Metrics
9 Record Views