Journal article
More than One Way To Control Hair Growth: Regulatory Mechanisms in Enterobacteria That Affect Fimbriae Assembled by the Chaperone/Usher Pathway
Journal of bacteriology, Vol.193(9), pp.2081-2088
05/01/2011
DOI: 10.1128/JB.00071-11
PMCID: PMC3133066
PMID: 21398554
Abstract
Many Gram-negative enterobacteria produce surface-associated fimbriae that facilitate attachment and adherence to eucaryotic cells and tissues. These organelles are believed to play an important role during infection by enabling bacteria to colonize specific niches within their hosts. One class of these fimbriae is assembled using a periplasmic chaperone and membrane-associated scaffolding protein that has been referred to as an usher because of its function in fimbrial biogenesis. The presence of multiple types of fimbriae assembled by the chaperone/usher pathway can be found both within a single bacterial species and also among different genera. One way of controlling fimbrial assembly in these bacteria is at the genetic level by positively or negatively regulating fimbrial gene expression. This minireview considers the mechanisms that have been described to control fimbrial gene expression and uses specific examples to demonstrate both unique and shared properties of such regulatory mechanisms.
Details
- Title: Subtitle
- More than One Way To Control Hair Growth: Regulatory Mechanisms in Enterobacteria That Affect Fimbriae Assembled by the Chaperone/Usher Pathway
- Creators
- Steven Clegg - University of IowaJanet Wilson - University of IowaJeremiah Johnson - University of Iowa
- Resource Type
- Journal article
- Publication Details
- Journal of bacteriology, Vol.193(9), pp.2081-2088
- Publisher
- Amer Soc Microbiology
- DOI
- 10.1128/JB.00071-11
- PMID
- 21398554
- PMCID
- PMC3133066
- ISSN
- 0021-9193
- eISSN
- 1098-5530
- Number of pages
- 8
- Grant note
- GM084318; AI1050011; AI074693; T32 AI007511 / NIH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA R01AI074693 / NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Allergy & Infectious Diseases (NIAID) R01GM084318 / NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of General Medical Sciences (NIGMS)
- Language
- English
- Date published
- 05/01/2011
- Academic Unit
- Microbiology and Immunology
- Record Identifier
- 9984696716602771
Metrics
2 Record Views