More than the oocyte source, egg donors as patients: a national picture of United States egg donors

Jennifer F Kawwass; Patrick Ten Eyck; Patrick Sieber; Heather S Hipp; Brad Van Voorhis

doi:10.1007/s10815-021-02178-1

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More than the oocyte source, egg donors as patients: a national picture of United States egg donors

Journal article

Open access

Peer reviewed

More than the oocyte source, egg donors as patients: a national picture of United States egg donors

Jennifer F Kawwass, Patrick Ten Eyck, Patrick Sieber, Heather S Hipp and Brad Van Voorhis

Journal of assisted reproduction and genetics, Vol.38(5), pp.1171-1175

05/2021

DOI: 10.1007/s10815-021-02178-1

PMCID: PMC8190211

PMID: 33797005

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8190211View

Published (Version of record) Open Access

Abstract

To characterize national oocyte donation practice patterns from the perspective of individual donors rather than of recipients. Retrospective cohort including all donor oocyte retrievals and transfers reported to SARTCORS in 2016 and 2017 in the USA. Primary outcomes include characteristics of oocyte donors and of donor oocyte cycles. Secondary outcomes include overall pregnancy rates, elective single embryo transfer (eSET) rates, and perinatal outcomes among donor oocyte recipient transfers. During the study period, 49,193 donor oocyte retrievals were performed, of which the largest proportion were in the Western US. For all reported retrievals, there were 17,099 unique donors, each of whom underwent an average of 2.4 retrievals (range 1-22). Average donor age was 26.3 years (range 18-48). On average, 24.6 oocytes (SD 12.4) were retrieved each cycle, ranging from 0 to 102. Among 37,657 donor oocyte recipient transfers, 20,159 (53.5%) involved eSET, and 17,725 (47.1%) resulted in live birth. Miscarriage rates were 17.5%, and good perinatal outcome (GPO), defined as full-term normal birthweight delivery, was more likely among singleton (75.7%) than multiple (23.8%) pregnancies. The average number of retrievals that donors underwent and oocyte yield mirrored national guidelines; however outliers, exist that may unnecessarily increase donor risk. Additionally, among resultant donor transfers, 46.5% transferred more than one embryo despite national recommendations for eSET. The significantly higher likelihood of GPO among singleton pregnancies points to the need to further increase donor recipient eSET rates.

Cryopreservation

Pregnancy

Abortion, Spontaneous - epidemiology

Abortion, Spontaneous - genetics

Abortion, Spontaneous - pathology

Adolescent

Adult

Embryo Transfer

Female

Fertilization in Vitro

Humans

Live Birth - epidemiology

Live Birth - genetics

Middle Aged

Oocyte Donation

Oocyte Retrieval

Oocytes - growth & development

Oocytes - pathology

Pregnancy Rate

Pregnancy, Multiple

Single Embryo Transfer - trends

Young Adult

Details

Title: Subtitle: More than the oocyte source, egg donors as patients: a national picture of United States egg donors
Creators: Jennifer F Kawwass - Division of Reproductive Endocrinology and Infertility, Department of Gynecology and Obstetrics, Emory Reproductive Center, Atlanta, USA
Patrick Ten Eyck - University of Iowa
Patrick Sieber - RedShift Technologies, Inc., New York, NY, USA.
Heather S Hipp - Division of Reproductive Endocrinology and Infertility, Department of Gynecology and Obstetrics, Emory Reproductive Center, 550 Peachtree Street, Suite 1800, Atlanta, GA 30308. USA
Brad Van Voorhis - Roy J. and Lucille A. Carver College of Medicine
Resource Type: Journal article
Publication Details: Journal of assisted reproduction and genetics, Vol.38(5), pp.1171-1175
DOI: 10.1007/s10815-021-02178-1
PMID: 33797005
PMCID: PMC8190211
ISSN: 1058-0468
eISSN: 1573-7330
Language: English
Date published: 05/2021
Academic Unit: Biostatistics; Obstetrics and Gynecology
Record Identifier: 9984318326802771

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5 Times Cited - Web of Science