Morpholino-driven gene editing: a new horizon for disease treatment and prevention

Ekaterina Subbotina; Siva Rama Krishna Koganti; Denice Hodgson-Zingman; Leonid V Zingman

doi:10.1002/cpt.276

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Morpholino-driven gene editing: a new horizon for disease treatment and prevention

Journal article

Peer reviewed

Morpholino-driven gene editing: a new horizon for disease treatment and prevention

Ekaterina Subbotina, Siva Rama Krishna Koganti, Denice Hodgson-Zingman and Leonid V Zingman

Clinical pharmacology and therapeutics, Vol.99(1), pp.21-25

01/2016

DOI: 10.1002/cpt.276

PMCID: PMC4720544

PMID: 26474085

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Abstract

The development of genetic and molecular biology tools permitting the connection of specific genes to their functions has accelerated our understanding of molecular pathways underlying health and disease. The resulting gains in knowledge have propelled gene targeting to the forefront of promising therapeutic strategies. Here we discuss the uniquely powerful and adaptable approach of morpholino-driven modification of normal and mutant gene expression as a pathway to health.

gene silencing

skeletal muscle

vivo-morpholino

oligonucleotide

ATP-sensitive potassium channel

Details

Title: Subtitle: Morpholino-driven gene editing: a new horizon for disease treatment and prevention
Creators: Ekaterina Subbotina - Department of Internal Medicine, Carver College of Medicine, University of Iowa, Iowa City, IA, USA
Siva Rama Krishna Koganti - Department of Internal Medicine, Carver College of Medicine, University of Iowa, Iowa City, IA, USA
Denice Hodgson-Zingman - Department of Internal Medicine, Carver College of Medicine, University of Iowa, Iowa City, IA, USA
Leonid V Zingman - Department of Internal Medicine, Carver College of Medicine, University of Iowa, Iowa City, IA, USA
Resource Type: Journal article
Publication Details: Clinical pharmacology and therapeutics, Vol.99(1), pp.21-25
DOI: 10.1002/cpt.276
PMID: 26474085
PMCID: PMC4720544
NLM abbreviation: Clin Pharmacol Ther
ISSN: 0009-9236
eISSN: 1532-6535
Grant note: DOI: 10.13039/100000002, name: National Institutes of Health, award: HL113089 to D. Hodgson-Zingman [University of Iowa, DK092412 to L. Zingman [University of Iowa; name: VA Merit Review Program, award: 1I0BX000718 to L. Zingman [University of Iowa
Language: English
Date published: 01/2016
Academic Unit: Roy J. Carver Department of Biomedical Engineering; Cardiovascular Medicine; Internal Medicine
Record Identifier: 9984094211602771

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