Journal article
Morphological characteristics of brain aneurysms among age groups
Interventional neuroradiology, pp.15910199231201520-15910199231201520
09/16/2023
DOI: 10.1177/15910199231201520
PMID: 37715650
Abstract
Background Patient's age is an important factor in determining the risk of aneurysm rupture. However, there is limited data on how aneurysm morphology differs among age groups. We studied morphological characteristics of brain aneurysms among age groups in a large cohort. Methods Aneurysms from the Stroke Thrombectomy and Aneurysm Registry (STAR) were analyzed. The following parameters were included: location, size, neck, width, height, aspect ratio, and regular versus irregular morphology. The risk of rupture presentation was estimated using logistic regression. Results A total of 1407 unruptured and 607 ruptured saccular aneurysms were included. The most common locations of ruptured aneurysms in patients younger than 70 years-old were the middle cerebral artery (MCA) and the anterior communicating artery (ACOM). The most common location of ruptured aneurysms in patients older than 70 years-old were the posterior communicating artery (PCOM) and ACOM. The size of unruptured aneurysms increased with age (p < .001). Conversely, the size of ruptured aneurysms was similar among age groups (p = .142). Unruptured and ruptured aneurysms became more irregular at presentation with older age (p < .001 and p .025, respectively). Irregular morphology and location were associated with rupture status across all age groups in multivariate regression. Conclusions Younger patients have small unruptured and ruptured aneurysms, and ruptured aneurysms are mostly located in the MCA and ACOM. Older patients have larger and more irregular unruptured aneurysms, and ruptured aneurysms are mostly located in the PCOM and ACOM. An irregular morphology increases the risk of rupture in all age groups.
Details
- Title: Subtitle
- Morphological characteristics of brain aneurysms among age groups
- Creators
- Sebastian Sanchez - University of IowaMuhammed Amir Essibayi - Medical University of South CarolinaDiego J Ojeda - University of IowaSami Al Kasab - Medical University of South CarolinaShinichi Yoshimura - Hyogo Medical UniversityPascal M. Jabbour - Thomas Jefferson UniversityJustin Mascitelli - The University of Texas Health Science Center at San AntonioMichael R. Levitt - University of WashingtonHugo H. Cuellar-Saenz - Louisiana State University Health Sciences Center ShreveportWaleed Brinjikji - Mayo Clinic in ArizonaAlejandro M. Spiotta - Medical University of South CarolinaAmir Shaban - University of IowaEdgar A Samaniego - University of Iowa
- Resource Type
- Journal article
- Publication Details
- Interventional neuroradiology, pp.15910199231201520-15910199231201520
- DOI
- 10.1177/15910199231201520
- PMID
- 37715650
- ISSN
- 1591-0199
- eISSN
- 2385-2011
- Language
- English
- Electronic publication date
- 09/16/2023
- Academic Unit
- Neurology; Radiology; Iowa Neuroscience Institute; Neurosurgery
- Record Identifier
- 9984466774302771
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