Morphology of the cerebral cortex in preclinical Huntington's disease

Peg Nopoulos; Vincent A Magnotta; Ania Mikos; Henry Paulson; Nancy C Andreasen; Jane S Paulsen

doi:10.1176/appi.ajp.2007.06081266

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Morphology of the cerebral cortex in preclinical Huntington's disease

Journal article

Peer reviewed

Morphology of the cerebral cortex in preclinical Huntington's disease

Peg Nopoulos, Vincent A Magnotta, Ania Mikos, Henry Paulson, Nancy C Andreasen and Jane S Paulsen

The American journal of psychiatry, Vol.164(9), pp.1428-1434

09/2007

DOI: 10.1176/appi.ajp.2007.06081266

PMID: 17728429

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Abstract

Cortical morphology was evaluated in subjects with known gene expansion for Huntington's disease and no manifest disease. Magnetic resonance imaging scans were obtained for 24 subjects with preclinical Huntington's disease and were compared to those for 24 matched healthy subjects by means of novel imaging methods to quantify aspects of cortical structure. In relation to the comparison subjects, those with preclinical Huntington's disease showed altered cortex morphology with enlargement of gyral crowns and abnormally thin sulci. These changes were manifested in global alterations of gyral and sulcal shape. These findings lend support to the notion that, in addition to the degenerative process, abnormal neural development may also be an important process in the pathoetiology of Huntington's disease.

Genetic Predisposition to Disease - genetics

Genetic Testing - statistics & numerical data

Humans

Huntington Disease - pathology

Cerebral Cortex - pathology

Male

Nerve Degeneration - pathology

Imaging, Three-Dimensional - statistics & numerical data

Magnetic Resonance Imaging - statistics & numerical data

Huntington Disease - genetics

Adult

Female

Huntington Disease - diagnosis

Hypertrophy

Details

Title: Subtitle: Morphology of the cerebral cortex in preclinical Huntington's disease
Creators: Peg Nopoulos - Department of Psychiatry, University of Iowa Roy and Lucille Carver College of Medicine, Iowa City, IA, USA. peggy-nopoulos@uiowa.edu
Vincent A Magnotta
Ania Mikos
Henry Paulson
Nancy C Andreasen
Jane S Paulsen
Resource Type: Journal article
Publication Details: The American journal of psychiatry, Vol.164(9), pp.1428-1434
Publisher: United States
DOI: 10.1176/appi.ajp.2007.06081266
PMID: 17728429
ISSN: 0002-953X
eISSN: 1535-7228
Grant note: MH-031593 / NIMH NIH HHS MH-60990 / NIMH NIH HHS MH-01579 / NIMH NIH HHS MH-40856 / NIMH NIH HHS NS-40068 / NINDS NIH HHS
Language: English
Date published: 09/2007
Academic Unit: Roy J. Carver Department of Biomedical Engineering; Neurology; Radiology; Psychiatry; Stead Family Department of Pediatrics; Psychological and Brain Sciences; Iowa Neuroscience Institute
Record Identifier: 9984004181302771

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