Morphology of the lateral superior temporal gyrus in neuroleptic naı̈ve patients with schizophrenia: relationship to symptoms

Jae-Jin Kim; Benedicto Crespo-Facorro; Nancy C Andreasen; Daniel S O'Leary; Vincent Magnotta; Peg Nopoulos

doi:10.1016/S0920-9964(02)00299-2

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Morphology of the lateral superior temporal gyrus in neuroleptic naı̈ve patients with schizophrenia: relationship to symptoms

Journal article

Peer reviewed

Morphology of the lateral superior temporal gyrus in neuroleptic naı̈ve patients with schizophrenia: relationship to symptoms

Jae-Jin Kim, Benedicto Crespo-Facorro, Nancy C Andreasen, Daniel S O'Leary, Vincent Magnotta and Peg Nopoulos

Schizophrenia research, Vol.60(2), pp.173-181

2003

DOI: 10.1016/S0920-9964(02)00299-2

PMID: 12591581

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https://ir.ymlib.yonsei.ac.kr/handle/22282913/114370View

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Abstract

Objective: The superior temporal gyrus (STG) is a large structure in the temporal lobe with multiple sub-regions that are structurally and functionally distinct. This study evaluates the structural morphology of a specific sub-region of the STG, the anterior and posterior portions of the lateral aspect of the STG. Furthermore, relationships between the morphology of these regions and symptoms of the illness were explored. Method: Regions of cortex were consecutively traced on a set of serial coronal slices in 25 male neuroleptic naı̈ve patients with first episode schizophrenia and 25 age-matched healthy volunteers. Regional gray matter volumes were calculated and compared, and their correlations with three symptom dimensions were explored. Results: The left anterior STG had a significant inverse correlation with psychotic symptoms, whereas the right posterior STG had a significant positive correlation with negative symptoms. These findings were confirmed by a follow-up analysis using extreme groups. There was no significant correlation between any region and disorganized symptoms. Conclusions: These findings suggest that abnormalities in the lateral side of the STG may be associated with both psychotic and negative symptoms through different pathophysiological mechanisms.

Neuroleptic naı̈ve patients

Schizophrenia

Superior temporal gyrus

Details

Title: Subtitle: Morphology of the lateral superior temporal gyrus in neuroleptic naı̈ve patients with schizophrenia: relationship to symptoms
Creators: Jae-Jin Kim - BK21 Human Life Sciences, Seoul National University, Seoul, South Korea
Benedicto Crespo-Facorro - Unidad de Investigacion en Psyquiatria, Hospital Universitario Marques de Valdecilla, Santander, Spain
Nancy C Andreasen - Mental Health-Clinical Research Center, Department of Psychiatry, College of Medicine, University of Iowa Hospitals and Clinics, 1-180 MEB, 500 Newton Road, Iowa City, IA 52242, USA
Daniel S O'Leary - Mental Health-Clinical Research Center, Department of Psychiatry, College of Medicine, University of Iowa Hospitals and Clinics, 1-180 MEB, 500 Newton Road, Iowa City, IA 52242, USA
Vincent Magnotta - Mental Health-Clinical Research Center, Department of Psychiatry, College of Medicine, University of Iowa Hospitals and Clinics, 1-180 MEB, 500 Newton Road, Iowa City, IA 52242, USA
Peg Nopoulos - Mental Health-Clinical Research Center, Department of Psychiatry, College of Medicine, University of Iowa Hospitals and Clinics, 1-180 MEB, 500 Newton Road, Iowa City, IA 52242, USA
Resource Type: Journal article
Publication Details: Schizophrenia research, Vol.60(2), pp.173-181
DOI: 10.1016/S0920-9964(02)00299-2
PMID: 12591581
NLM abbreviation: Schizophr Res
ISSN: 0920-9964
eISSN: 1573-2509
Publisher: Elsevier B.V
Language: English
Date published: 2003
Academic Unit: Roy J. Carver Department of Biomedical Engineering; Neurology; Radiology; Psychiatry; Stead Family Department of Pediatrics; Iowa Neuroscience Institute
Record Identifier: 9984003477602771

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