Journal article
Morphology of the ventral frontal cortex in schizophrenia: relationship with social dysfunction
Biological psychiatry (1969), Vol.52(1), pp.1-8
2002
DOI: 10.1016/S0006-3223(01)01363-4
PMID: 12079724
Abstract
Background: Studies have reported premorbid as well as postonset social dysfunction in schizophrenia. This impairment has also been observed to emerge after lesions in the ventral aspect of the frontal cortex (i.e., straight gyrus and orbitofrontal cortex).
Methods: Magnetic resonance imaging scans were obtained from 45 male patients with schizophrenia and 45 matched control subjects. Cortical gray matter volume and surface area were determined for the ventral frontal cortex (VFC), subdivided into the orbitofrontal cortex (OFC) and the straight gyrus (SG).
Results: The global measures of gray matter volume and surface area in the VFC was not significantly different between patients and control subjects; however, there was a regional difference, with the right SG volume and surface area being smaller in patients compared with control subjects. Volume of the VFC had an inverse correlation with measurements of both premorbid and postdiagnosis social function. The smaller the gray matter in these regions, the greater the social dysfunction. There was no relationship between morphology of this brain region and any other clinical variable.
Conclusions: Morphology of the VFC is directly related to abnormal social function in schizophrenia, including measures of social dysfunction that predate the onset of illness.
Details
- Title: Subtitle
- Morphology of the ventral frontal cortex in schizophrenia: relationship with social dysfunction
- Creators
- Eran Chemerinski - Mental Health-Clinical Research Center, Department of Psychiatry, College of Medicine, University of Iowa Hospitals and Clinics, Iowa City, Iowa, USAPeggy C Nopoulos - Mental Health-Clinical Research Center, Department of Psychiatry, College of Medicine, University of Iowa Hospitals and Clinics, Iowa City, Iowa, USABenedicto Crespo-Facorro - Mental Health-Clinical Research Center, Department of Psychiatry, College of Medicine, University of Iowa Hospitals and Clinics, Iowa City, Iowa, USANancy C Andreasen - Mental Health-Clinical Research Center, Department of Psychiatry, College of Medicine, University of Iowa Hospitals and Clinics, Iowa City, Iowa, USAVincent Magnotta - Mental Health-Clinical Research Center, Department of Psychiatry, College of Medicine, University of Iowa Hospitals and Clinics, Iowa City, Iowa, USA
- Resource Type
- Journal article
- Publication Details
- Biological psychiatry (1969), Vol.52(1), pp.1-8
- Publisher
- Elsevier Inc
- DOI
- 10.1016/S0006-3223(01)01363-4
- PMID
- 12079724
- ISSN
- 0006-3223
- eISSN
- 1873-2402
- Language
- English
- Date published
- 2002
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Neurology; Radiology; Psychiatry; Stead Family Department of Pediatrics; Iowa Neuroscience Institute
- Record Identifier
- 9984003469802771
Metrics
27 Record Views