Journal article
Morphometric analysis of brain shape in children with nonsyndromic cleft lip and/or palate
Journal of child neurology, Vol.29(12), pp.1616-1625
12/2014
DOI: 10.1177/0883073813510603
PMCID: PMC4221570
PMID: 24381208
Abstract
The purpose of this study was to test for differences in brain shape among children with cleft palate only (n = 22), children with cleft lip and palate (n = 35), and controls (n = 39) using Euclidean distance matrix analysis. Sixteen percent of interlandmark distances differed between children with cleft palate only and controls, 10% differed between children with cleft lip and palate and controls, and 10% differed between children with cleft palate only and children with cleft lip and palate. Major differences in brain shape associated with cleft lip and/or palate included posterior expansion of the occipital lobe, reorientation of the cerebellum, heightened callosal midbody, and posterior displacement of the caudate nucleus and thalamus. Differences in brain shape unique to cleft palate only and to cleft lip and palate were also identified. These results expand upon previous volumetric studies on brain morphology in individuals with cleft lip and/or palate and provide additional evidence that the primary defect in cleft lip and/or palate results in both facial and brain dysmorphology.
Details
- Title: Subtitle
- Morphometric analysis of brain shape in children with nonsyndromic cleft lip and/or palate
- Creators
- Madeleine B Chollet - Johns Hopkins University School of Medicine, Baltimore, MD, USA Washington University School of Medicine, St. Louis, MO, USA cholletm@wusm.wustl.eduValerie B DeLeon - Johns Hopkins University School of Medicine, Baltimore, MD, USAAmy L Conrad - University of Iowa Carver College of Medicine, Iowa City, IA, USAPeg Nopoulos - University of Iowa Carver College of Medicine, Iowa City, IA, USA
- Resource Type
- Journal article
- Publication Details
- Journal of child neurology, Vol.29(12), pp.1616-1625
- DOI
- 10.1177/0883073813510603
- PMID
- 24381208
- PMCID
- PMC4221570
- NLM abbreviation
- J Child Neurol
- ISSN
- 0883-0738
- eISSN
- 1708-8283
- Publisher
- United States
- Grant note
- 5 R01 DE014399-05 / NIDCR NIH HHS F31 DE021302-01 / NIDCR NIH HHS F31 DE021302 / NIDCR NIH HHS R01 DE014399 / NIDCR NIH HHS
- Language
- English
- Date published
- 12/2014
- Academic Unit
- Neurology; Psychiatry; Pediatric Psychology; Stead Family Department of Pediatrics; Iowa Neuroscience Institute; Craniofacial Anomalies Research Center
- Record Identifier
- 9984065398002771
Metrics
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