Journal article
Mortality Associated with Healthy Eating Index Components and an Empirical-Scores Healthy Eating Index in a Cohort of Postmenopausal Women
The Journal of nutrition, Vol.152(11), pp.2493-2504
11/09/2022
DOI: 10.1093/jn/nxac068
PMCID: PMC9644175
PMID: 35289897
Abstract
Background Studies of diet and chronic disease include a recent important focus on dietary patterns. Patterns are typically defined by listing dietary variables and by totaling scores that reflect whether consumption is encouraged or discouraged for listed variables. However, precision may be improved by including total energy consumption among the dietary variables and by scoring dietary variables empirically. Objectives To relate Healthy Eating Index (HEI)-2010 components and total energy intake to all-cause and cause-specific mortality in Women's Health Initiative (WHI) cohorts and to define and evaluate an associated Empirical-Scores Healthy Eating Index (E-HEI). Methods Analyses are conducted in WHI cohorts (n = 67,247) of healthy postmenopausal women, aged 50-79 y, when enrolled during 1993-1998 at 40 US clinical centers, with embedded nutrition biomarker studies. Replicate food-frequency assessments for HEI-2010 ratio variables and doubly labeled water total energy assessments, separated by similar to 6 mo, are used as response variables to jointly calibrate baseline dietary data to reduce measurement error influences, using 2 nutrition biomarker studies (n = 199). Calibrated dietary variables are associated with mortality risk, and an E-HEI is defined, using cross-validated HR regression estimation. Results Of 15 dietary variables considered, all but empty calories calibrated well. Ten variables related significantly (P < 0.05) to total mortality, with favorable fruit, vegetable, whole grain, refined grain, and unsaturated fat associations and unfavorable sodium, saturated fat, and total energy associations. The E-HEI had cross-validated total mortality HRs (95% CIs) of 0.87 (0.82, 0.93), 0.80 (0.76, 0.86), 0.77 (0.72, 0.82), and 0.74 (0.69, 0.79) respectively, for quintiles 2 through 5 compared with quintile 1. These depart more strongly from the null than do HRs for HEI-2010 quintiles, primarily because of total energy. Conclusions Mortality among US postmenopausal women depends strongly on diet, as evidenced by a new E-HEI that differs substantially from earlier dietary pattern score specifications.
Details
- Title: Subtitle
- Mortality Associated with Healthy Eating Index Components and an Empirical-Scores Healthy Eating Index in a Cohort of Postmenopausal Women
- Creators
- Ross L. Prentice - Fred Hutch Cancer CenterAaron K. Aragaki - Fred Hutch Cancer CenterLinda Van Horn - Northwestern UniversityCynthia A. Thomson - University of ArizonaLesley F. Tinker - Fred Hutch Cancer CenterJoAnn E. Manson - Brigham and Women's HospitalYasmin Mossavar-Rahmani - Albert Einstein College of MedicineYing Huang - Fred Hutch Cancer CenterCheng Zheng - University of Nebraska Medical CenterShirley A. A. Beresford - University of WashingtonRobert Wallace - University of IowaGarnet L. Anderson - Fred Hutch Cancer CenterJohanna W. Lampe - Fred Hutch Cancer CenterMarian L. Neuhouser - Fred Hutch Cancer Center
- Resource Type
- Journal article
- Publication Details
- The Journal of nutrition, Vol.152(11), pp.2493-2504
- DOI
- 10.1093/jn/nxac068
- PMID
- 35289897
- PMCID
- PMC9644175
- NLM abbreviation
- J Nutr
- ISSN
- 0022-3166
- eISSN
- 1541-6100
- Publisher
- Oxford Univ Press
- Number of pages
- 12
- Grant note
- DOI: 10.13039/100000016, name: U.S. Department of Health and Human Services, award: HHSN268201100046C, HHSN268201600001C, HHSN268201600002C, HHSN268201600003C, HHSN268201600004C, HHSN271201600004C; DOI: 10.13039/100000054, name: National Cancer Institute, award: CA119171
- Language
- English
- Date published
- 11/09/2022
- Academic Unit
- Epidemiology; Injury Prevention Research Center; Internal Medicine
- Record Identifier
- 9984364423402771
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