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Mortality Correlates in Patients With Takotsubo Syndrome During the COVID-19 Pandemic
Journal article   Open access

Mortality Correlates in Patients With Takotsubo Syndrome During the COVID-19 Pandemic

Amanda Chang, Yi Grace Wang, Manju B Jayanna, Xiaodong Wu, Linda M Cadaret and Kan Liu
Mayo Clinic proceedings. Innovations, quality & outcomes, Vol.5(6), pp.1050-1055
12/2021
DOI: 10.1016/j.mayocpiqo.2021.09.008
PMCID: PMC8479536
PMID: 34604705
url
https://doi.org/10.1016/j.mayocpiqo.2021.09.008View
Published (Version of record) Open Access

Abstract

We completed a systematic review of Takotsubo syndrome (TTS) cases reported during the coronavirus disease 2019 (COVID-19) pandemic and performed clustering and feature importance analysis and statistical testing for independence on the demographic, clinical, and imaging parameters. Compared with the data before the COVID-19 pandemic, TTS was increasingly diagnosed in physical stress (mostly COVID-19 pneumonia)–triggered male patients without psychiatric/neurologic disorders, warranting further investigation to establish new reference criteria to improve diagnostic specificity. In clustering analysis, sex and inpatient mortality primarily contributed to the automated classification of the TTS. Both sex and inpatient mortality had essential correlations with COVID-19 infection/pneumonia. There is effect modification of sex on outcomes in patients with COVID-19 infection and TTS, with male patients having significantly worse inpatient mortality. Meanwhile, significantly more male patients with TTS were classified as high risk according to International Takotsubo Registry prognostic scores, suggesting that male COVID-19/TTS survivors will likely have worse long-term outcome.
 COVID-19 TTS InterTAK AMI

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