Mortality and Morbidity of VLBW Infants With Trisomy 13 or Trisomy 18

Nansi S BOGHOSSIAN; Nellie I HANSEN; Roger G FAIX; Nancy S NEWMAN; Ellen C HALE; Abhik DAS; Leslie D WILSON; Angelita M HENSMAN; Cathy GRISBY; Monica V COLLINS; Diana M VASIL; Joanne FINKLE; Edward F BELL; Deanna MAFFETT; M. Bethany BALL; Conra B LACY; Rebecca BARA; Rosemary D HIGGINS; Barbara J STOLL; Jeffrey C MURRAY; John C CAREY; Ira ADAMS-CHAPMAN; Seetha SHANKARAN; Michele C WA; Abbot R LAPTOOK

doi:10.1542/peds.2013-1702

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Mortality and Morbidity of VLBW Infants With Trisomy 13 or Trisomy 18

Journal article

Open access

Peer reviewed

Mortality and Morbidity of VLBW Infants With Trisomy 13 or Trisomy 18

Nansi S BOGHOSSIAN, Nellie I HANSEN, Roger G FAIX, Nancy S NEWMAN, Ellen C HALE, Abhik DAS, Leslie D WILSON, Angelita M HENSMAN, Cathy GRISBY, Monica V COLLINS, …

Pediatrics (Evanston), Vol.133(2), pp.226-235

2014

DOI: 10.1542/peds.2013-1702

PMCID: PMC3904274

PMID: 24446439

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Abstract

Objective: Little is known about how very low birth weight (VLBW) affects survival and morbidities among infants with trisomy 13 (T13) or trisomy 18 (T18). We examined the care plans for VLBW infants with T13 or T18 and compared their risks of mortality and neonatal morbidities with VLBW infants with trisomy 21 and VLBW infants without birth defects. Methods: Infants with birth weight 401 to 1500 g born or cared for at a participating center of the Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network during the period 1994-2009 were studied. Poisson regression models were used to examine risk of death and neonatal morbidities among infants with T13 or T18. Results: Of 52,262 VLBW infants, 38 (0.07%) had T13 and 128 (0.24%) had T18. Intensity of care in the delivery room varied depending on whether the trisomy was diagnosed before or after birth. The plan for subsequent care for the majority of the infants was to withdraw care or to provide comfort care. Eleven percent of infants with T13 and 9% of infants with T18 survived to hospital discharge. Survivors with T13 or T18 had significantly increased risk of patent ductus arteriosus and respiratory distress syndrome compared with infants without birth defects. No infant with T13 or T18 developed necrotizing enterocolitis. Conclusions: In this cohort of liveborn VLBW infants with T13 or T18, the timing of trisomy diagnosis affected the plan for care, survival was poor, and death usually occurred early.

Medical Genetics

Epidemiology

Public health. Hygiene-occupational medicine

Public health. Hygiene

General aspects

Biological and medical sciences

Medical sciences

Chromosome aberrations

Details

Title: Subtitle: Mortality and Morbidity of VLBW Infants With Trisomy 13 or Trisomy 18
Creators: Nansi S BOGHOSSIAN - Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, Maryland, United States
Nellie I HANSEN - Social, Statistical and Environmental Sciences Unit, RTI International, Research Triangle Park, North Carolina, United States
Roger G FAIX - Department of Pediatrics, University of Utah, Salt Lake City, Utah, United States
Nancy S NEWMAN - Department of Pediatrics, Case Western Reserve University and Rainbow Babies & Children's Hospital, Cleveland, Ohio, United States
Ellen C HALE - Department of Pediatrics, Emory University School of Medicine and Children's Healthcare of Atlanta, Atlanta, Georgia, United States
Abhik DAS - Social, Statistical and Environmental Sciences Unit, RTI International, Rockville, Maryland, United States
Leslie D WILSON - Department of Pediatrics, Indiana University School of Medicine, Indianapolis, Indiana, United States
Angelita M HENSMAN - Department of Pediatrics, Brown University and Women & Infants Hospital of Rhode Island, Providence, Rhode Island, United States
Cathy GRISBY - Perinatal Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, United States
Monica V COLLINS - Department of Pediatrics, University of Alabama at Birmingham, Birmingham, Alabama, United States
Diana M VASIL - Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas, United States
Joanne FINKLE - Department of Pediatrics, Duke University, Durham, North Carolina, United States
Edward F BELL - Department of Pediatrics, University of Iowa, Iowa City, Iowa, United States
Deanna MAFFETT - Department of Pediatrics, University of Rochester School of Medicine and Dentistry, Rochester, New York, United States
M. Bethany BALL - Department of Pediatrics, Stanford University School of Medicine and Lucile Packard Children's Hospital, Palo Alto, California, United States
Conra B LACY - Department of Pediatrics, University of New Mexico Health Sciences Center, Albuquerque, New Mexico, United States
Rebecca BARA - Department of Pediatrics, Wayne State University, Detroit, Michigan, United States
Rosemary D HIGGINS - Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, Maryland, United States
Barbara J STOLL - Department of Pediatrics, Emory University School of Medicine and Children's Healthcare of Atlanta, Atlanta, Georgia, United States
Jeffrey C MURRAY - Department of Pediatrics, University of Iowa, Iowa City, Iowa, United States
John C CAREY - Department of Pediatrics, University of Utah, Salt Lake City, Utah, United States
Ira ADAMS-CHAPMAN - Department of Pediatrics, Emory University School of Medicine and Children's Healthcare of Atlanta, Atlanta, Georgia, United States
Seetha SHANKARAN - Department of Pediatrics, Wayne State University, Detroit, Michigan, United States
Michele C WA - Department of Pediatrics, Case Western Reserve University and Rainbow Babies & Children's Hospital, Cleveland, Ohio, United States
Abbot R LAPTOOK - Department of Pediatrics, Brown University and Women & Infants Hospital of Rhode Island, Providence, Rhode Island, United States
Resource Type: Journal article
Publication Details: Pediatrics (Evanston), Vol.133(2), pp.226-235
DOI: 10.1542/peds.2013-1702
PMID: 24446439
PMCID: PMC3904274
NLM abbreviation: Pediatrics
ISSN: 0031-4005
eISSN: 1098-4275
Publisher: American Academy of Pediatrics; Elk Grove Village, IL
Language: English
Date published: 2014
Academic Unit: Anatomy and Cell Biology; Stead Family Department of Pediatrics; Epidemiology; Pediatric Dentistry; Craniofacial Anomalies Research Center; Dental Research; Neonatology
Record Identifier: 9984025480002771

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