Journal article
Mortality in patients with small choroidal melanoma. COMS report no. 4. The Collaborative Ocular Melanoma Study Group
Archives of ophthalmology (1960), Vol.115(7), pp.886-893
07/01/1997
DOI: 10.1001/archopht.1997.01100160056009
PMID: 9230829
Abstract
OBJECTIVETo describe the clinical characteristics and survival experience of a prospectively followed up group of patients with small choroidal melanoma.METHODSThe Collaborative Ocular Melanoma Study (COMS) is a set of clinical trials designed to compare the role of radiotherapy and enucleation in the treatment of medium and large-size choroidal melanoma. From December 1986 to August 1989, patients with small choroidal melanoma, not large enough to be eligible for the COMS clinical trials, were offered participation in a nonrandomized prospective follow-up study. Small choroidal melanomas were defined as 1.0 to 3.0 mm in apical height and at least 5.0 mm in basal diameter. A total of 204 patients were enrolled in the study. Patients were followed up annually through August 1989. Two additional assessments of treatment status and mortality were conducted in 1993-1994 and 1995-1996. The median length of follow-up was 92 months. Eight percent of patients were treated at the time of study enrollment and an additional 33% were treated during follow-up.RESULTSTwenty-seven patients have died; 6 deaths were reported by the clinical center as due to metastatic melanoma. The Kaplan-Meier estimate of 5-year all-cause mortality was 6.0% (95% confidence interval, 2.7%-9.3%) and 8-year all-cause mortality was 14.9% (95% confidence interval, 9.6%-20.2%).CONCLUSIONSOtherwise healthy patients, average age of 60 years, without a previous diagnosis of malignant disease who have small choroidal lesions judged to be melanoma have a low risk of dying within 5 years.
Details
- Title: Subtitle
- Mortality in patients with small choroidal melanoma. COMS report no. 4. The Collaborative Ocular Melanoma Study Group
- Creators
- Collaborative Ocular Melanoma Study Group
- Contributors
- H Culver Boldt (Contributor) - University of Iowa, Ophthalmology and Visual Sciences
- Resource Type
- Journal article
- Publication Details
- Archives of ophthalmology (1960), Vol.115(7), pp.886-893
- DOI
- 10.1001/archopht.1997.01100160056009
- PMID
- 9230829
- NLM abbreviation
- Arch Ophthalmol
- ISSN
- 0003-9950
- eISSN
- 1538-3601
- Publisher
- American Medical Association
- Language
- English
- Date published
- 07/01/1997
- Academic Unit
- Ophthalmology and Visual Sciences
- Record Identifier
- 9984083839302771
Metrics
59 Record Views