Mortality patterns related to stroke and dementia among older adults in the U. S.: a CDC WONDER analysis from 1999 to 2024

Maryam Saghir; Eshal Saghir; Maliha Khalid; Muhammad Umar; Sahil Jairamani; Areej Dar; Hasiba Karimi; Muhammad Khalid Afridi; Syed Ijlal Ahmed; Jamal S. Rana; Elangovan Krishnan; Ishtiaq Ahmad; Suleman Sofian Suliman

doi:10.3389/fneur.2026.1889772

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Mortality patterns related to stroke and dementia among older adults in the U. S.: a CDC WONDER analysis from 1999 to 2024

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Mortality patterns related to stroke and dementia among older adults in the U. S.: a CDC WONDER analysis from 1999 to 2024

Maryam Saghir, Eshal Saghir, Maliha Khalid, Muhammad Umar, Sahil Jairamani, Areej Dar, Hasiba Karimi, Muhammad Khalid Afridi, Syed Ijlal Ahmed, Jamal S. Rana, …

Frontiers in neurology, Vol.17, 1889772

08/26/2026

DOI: 10.3389/fneur.2026.1889772

PMCID: PMC13555609

PMID: 42719173

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Abstract

Introduction: Blood flow impairment due to stroke substantially causes neuronal loss, ultimately leading to cognitive decline. Dementia is a progressive neurocognitive disorder that represents a major public health challenge worldwide. Methods: We analyzed stroke and dementia related mortality trends among older adults using the Centers for Disease Control and Prevention Wide-Ranging Online Data for Epidemiologic Research (CDC WONDER) database from 1999 to 2024. Age-Adjusted Mortality Rates (AAMRs) per 100,000 were calculated and categorized by demographics and region. Joinpoint regression was used to estimate Annual Percent Change (APC) and Average Annual Percent Change (AAPC). Results: A total of 965,793 deaths due to stroke and dementia among older adults aged ≥65 years were recorded. Among the subgroups of dementia, unspecified dementia reported the greatest mortality. The AAMR observed a steep incline from 69.34 in 1999 to 99.25 in 2024. Older females observed higher overall AAMR than older males. Racially, Non-Hispanic Black population had the highest overall AAMR. Regionally, the highest overall AAMR was recorded by the Southern U. S. Despite COVID-19, the post pandemic era observed increasing mortality. Conclusion: Our cohort exhibited a rise in mortality rates among elderly with stroke and dementia, underscoring the need for preventive strategies, and targeted interventions in vulnerable populations and regions.

dementia

epidemiology

mortality trends

retrospective analysis

stroke

Details

Title: Subtitle: Mortality patterns related to stroke and dementia among older adults in the U. S.: a CDC WONDER analysis from 1999 to 2024
Creators: Maryam Saghir - Jinnah Sindh Medical University
Eshal Saghir - Dow University of Health Sciences
Maliha Khalid - Jinnah Sindh Medical University
Muhammad Umar
Sahil Jairamani - Liaquat University of Medical & Health Sciences
Areej Dar - Khost University
Hasiba Karimi - Bezmiâlem Vakıf Üniversitesi
Muhammad Khalid Afridi - Dow University of Health Sciences
Syed Ijlal Ahmed - Saint Francis Medical Center
Jamal S. Rana - Kaiser Permanente
Elangovan Krishnan - University of Louisville
Ishtiaq Ahmad - University of Iowa
Suleman Sofian Suliman - National Ribat University
Resource Type: Journal article
Publication Details: Frontiers in neurology, Vol.17, 1889772
DOI: 10.3389/fneur.2026.1889772
PMID: 42719173
PMCID: PMC13555609
NLM abbreviation: Front Neurol
ISSN: 1664-2295
eISSN: 1664-2295
Publisher: Frontiers Media SA
Language: English
Date published: 08/26/2026
Academic Unit: Internal Medicine
Record Identifier: 9985222046602771

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