Journal article
Mosaic RBD Nanoparticles Elicit Protective Immunity Against Multiple Human Coronaviruses in Animal Models
Advanced science, Vol.11(9), e2303366
03/2024
DOI: 10.1002/advs.202303366
PMCID: PMC10916629
PMID: 38105421
Abstract
To combat SARS-CoV-2 variants and MERS-CoV, as well as the potential re-emergence of SARS-CoV and spillovers of sarbecoviruses, which pose a significant threat to global public health, vaccines that can confer broad-spectrum protection against betacoronaviruses (β-CoVs) are urgently needed. A mosaic ferritin nanoparticle vaccine is developed that co-displays the spike receptor-binding domains of SARS-CoV, MERS-CoV, and SARS-CoV-2 Wild-type (WT) strain and evaluated its immunogenicity and protective efficacy in mice and nonhuman primates. A low dose of 10 µg administered at a 21-day interval induced a Th1-biased immune response in mice and elicited robust cross-reactive neutralizing antibody responses against a variety of β-CoVs, including a series of SARS-CoV-2 variants. It is also able to effectively protect against challenges of SARS-CoV, MERS-CoV, and SARS-CoV-2 variants in not only young mice but also the more vulnerable mice through induction of long-lived immunity. Together, these results suggest that this mosaic 3-RBD nanoparticle has the potential to be developed as a pan-β-CoV vaccine.
Details
- Title: Subtitle
- Mosaic RBD Nanoparticles Elicit Protective Immunity Against Multiple Human Coronaviruses in Animal Models
- Creators
- Yanjun Zhang - First Affiliated Hospital of Guangzhou Medical UniversityJing Sun - First Affiliated Hospital of Guangzhou Medical UniversityJian Zheng - University of IowaSuxiang Li - First Affiliated Hospital of Guangzhou Medical UniversityHaiyue Rao - First Affiliated Hospital of Guangzhou Medical UniversityJun Dai - Guangzhou Customs District Technology Center, Guangzhou, 510700, P. R. ChinaZhaoyong Zhang - First Affiliated Hospital of Guangzhou Medical UniversityYanqun Wang - First Affiliated Hospital of Guangzhou Medical UniversityDonglan Liu - First Affiliated Hospital of Guangzhou Medical UniversityZhao Chen - First Affiliated Hospital of Guangzhou Medical UniversityWei Ran - First Affiliated Hospital of Guangzhou Medical UniversityAiru Zhu - First Affiliated Hospital of Guangzhou Medical UniversityFang Li - First Affiliated Hospital of Guangzhou Medical UniversityQihong Yan - First Affiliated Hospital of Guangzhou Medical UniversityYiliang Wang - First Affiliated Hospital of Guangzhou Medical UniversityKuai Yu - First Affiliated Hospital of Guangzhou Medical UniversityShengnan Zhang - First Affiliated Hospital of Guangzhou Medical UniversityDong Wang - First Affiliated Hospital of Guangzhou Medical UniversityYanhong Tang - First Affiliated Hospital of Guangzhou Medical UniversityBanghui Liu - State Key Laboratory of Respiratory DiseaseLinling Cheng - First Affiliated Hospital of Guangzhou Medical UniversityJiandong Huo - First Affiliated Hospital of Guangzhou Medical UniversityStanley Perlman - University of IowaJingxian Zhao - First Affiliated Hospital of Guangzhou Medical UniversityJincun Zhao - ShanghaiTech University
- Resource Type
- Journal article
- Publication Details
- Advanced science, Vol.11(9), e2303366
- DOI
- 10.1002/advs.202303366
- PMID
- 38105421
- PMCID
- PMC10916629
- NLM abbreviation
- Adv Sci (Weinh)
- eISSN
- 2198-3844
- Grant note
- 2021A1111100009 JD / Guangdong Basic and Applied Basic Research Foundation 82025001 JZ / National Natural Science Foundation of China 2021B1212030016 JD / Guangdong Basic and Applied Basic Research Foundation 82172240 YW / National Natural Science Foundation of China 2021YFC2301700 CF / National Key R&D Program of China 82001750 YZ / National Natural Science Foundation of China 2023B1515020040 YW / Guangdong Basic and Applied Basic Research Foundation 82170003 LC / National Natural Science Foundation of China 2021B1515130005 JXZ / Guangdong Basic and Applied Basic Research Foundation Basic and Applied Basic Research Foundation of Guangdong Province ZNSA-2020013 / Guangdong Medical Research Foundation 122012-2 / Korea Institute of Planning and Evaluation for Technology in Food, Agriculture and Forestry (IPET) through Animal Disease Management Technology Advancement Support Program, funded by the Ministry of Agriculture, Food and Rural Affairs (MAFRA) 122060-2 / Korea Institute of Planning and Evaluation for Technology in Food, Agriculture and Forestry (IPET) through Animal Disease Management Technology Advancement Support Program, funded by the Ministry of Agriculture, Food and Rural Affairs (MAFRA) 2022B1515020059 / Guangdong Basic and Applied Basic Research Foundation 2019B1515120068 JCZ / Guangdong Basic and Applied Basic Research Foundation 2022B1515020059 JS / Guangdong Basic and Applied Basic Research Foundation
- Language
- English
- Electronic publication date
- 12/17/2023
- Date published
- 03/2024
- Academic Unit
- Microbiology and Immunology; Stead Family Department of Pediatrics; Iowa Neuroscience Institute; Infectious Disease (Pediatrics)
- Record Identifier
- 9984533453502771
Metrics
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